Discussion: (2018) (K122R 69.3% on the S region compared to 8.9% R122K in our study).
Discussion: We found mutations as Y100C/F, P120S/T, R122K, I126T/N/S, S132P, M133T/S/L/I, G145R (the vaccine escape mutant, 2%), Y200F/W and Y206H/F/C as same as that were reported from other studies (Hudu et al.
Molecular characterization of hepatitis B virus in blood donors in Botswana.
Discussion: In Turkey, the most frequent mutations observed were T143M and K122R, whereas in Egypt 14.8% presented with mutations in the MHR, and eight different mutations were discovered: R122K, S143L, L109P, S114P, Discussion: The prevalence of HBsAg escape mutants in Jordan was 18.9%, with the R122K mutation which affects HBV detection being the most prevalent type.
Discussion: This is comparable to a study done in Iran, which showed that the frequency of 14% major hydrophilic region mutations (MHR), with the most frequent ones of P120T/S and R122K/T.
Molecular Epidemiology of Hepatitis B Virus in Turkish Cypriot.
PMID: 31880889
2019
Polish journal of microbiology
Table: R122K
Investigation of a Novel Hepatitis B Virus Surface Antigen (HBsAg) Escape Mutant Affecting Immunogenicity.
Discussion: found no reactivity of HBsAg using two commercial diagnostic assays whose sequences had simultaneous mutations at various positions, including an amino acid at 100 (Y100S), and this may have been due to mutations at other sites (T118V/R122K/M133I/Y134N/P142S/S143L/G145K).
F221Y mutation in hepatitis B virus reverse transcriptase is associated with hepatocellular carcinoma prognosis following liver resection.
Result: Those omitted included R122K which is the determinant for subtyping HBsAg as ad versus ay, T126I for genotype C, A128V for genotype D2, and T131N for genotype A1.
Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India.
Result: Other diagnostic escape mutations found in the surface ORF were sR122K (5.9%), sG145A (5.9%), and sW172* (5.9%).
Table: R122K
Discussion: Further sequence analysis revealed other mutations such as sR122K, s
Discussion: The presence of both sR122K and sG145A had been earlier reported among the occult patients from the US, where the combined presence of these two mutations resulted in decreased levels of HBsAg in vitro.
New broadly reactive neutralizing antibodies against hepatitis B virus surface antigen.
Abstract: Certain aa residues at position 122 (either R or K) define different HBV serotypes (either d or y), therefore, the affinity of the MAb HB1 for the epitope with R122K substitution was determined to evaluate its diagnostic potential.
Serologic and genotypic characterization of hepatitis B virus in HIV-1 infected patients from South West and Littoral Regions of Cameroon.
Abstract: Escape mutations associated with failure of diagnosis (Y100C, R122K and Q129H) and with vaccine escape (Q129R and T131N) were detected in varying frequencies in the population.
Table: R122K
Discussion: There were three escape mutations identified which were previously associated with diagnostic failure (Y100C, R122K and Q129H) and two associated with vaccine escape (Q129H and T131N).
HBV mutation literature information.
PMID: 
2022
PloS one
Browser Board
Co-occurred Entities
Filtrator
ViMRT