Result: In respect to PC mutations, co-distribution of the overall PC mutations and ADV resistance gene variants (rtQ215H and rtI233V) were common during HIV co-infection.
Result: Other than the YMDD RT motif associated HBV drug resistance, none of the HIV co-infected patients who developed 16.7% (8/48) of ADV associated gene mutations (rtQ215H and rtI233V) revealed BCP double mutations (Table 3).
Table:
Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression.
PMID: 29713126
2018
World journal of gastroenterology
Table: Q215E/H
Pre-existing mutations related to tenofovir in chronic hepatitis B patients with long-term nucleos(t)ide analogue drugs treatment by ultra-deep pyrosequencing.
Result: Other substitutions (rtI169T/V, rtP177G, rtT184A/I, rtA194V/T, rtV214A, rtQ215R/H, rtF249A, and rtM250V) were present at low levels (<1%).
Dynamics of Genotypic Mutations of the Hepatitis B Virus Associated With Long-Term Entecavir Treatment Determined With Ultradeep Pyrosequencing: A Retrospective Observational Study.
Result: Eight patients harbored rtM204I/V substitutions of at least 1% (ranging from 1% to 3.6%); 2 of these patients also presented rtL180 M substitutions (2.3% and 2.4%) and rtS202G substitutio
Result: Other substitutions (rtI169T/V, rtV173A/M, rtT184A/I, rtA194 V/T, rtQ215R/H, rtM250 V) were presented at low levels (<1%).
Occult HBV Infection May Be Transmitted through Close Contact and Manifest as an Overt Infection.
Result: There are twenty-one amino acid substitutions in the overlapping polymerase in all clones from father's sample, including F46S, R51K, H55Q, H55R, S57F, P109S, N118T, N124R, Y124H, Q125R, H126Q, 127R, N134D, C136R, N139K, Y141F, S143T, H160R, A211T, S213T and Q215H
[HBV vaccine escape mutations in a chronic hepatitis B patient treated with nucleos(t)ide analogues].
Abstract: Primary drug resistance mutations (rtV173L + rtL180M + rtM204V) to lamivudine and telbivudine and a compensatory mutation (rtQ215H) to lamivudine and adefovir were described in the HBV pol gene sequence.
Quasispecies and pre-existing drug-resistant mutations of hepatitis B virus in patients with chronic hepatitis B.
Abstract: Patient 4 had mutations at T128N (1%), I169L (1%), V173L (2%), A181V (1%), and Q215H (1%).
Discussion: In addition to classical ADV resistance mutations such as rtN236S or rtA181T, a few other related-variants including rtV84I/S, rtL84S, and rtQ215H were identified before VB in patient 1, 3, 4, and 6.
Discussion: Regarding HBV quasispecies associated with ADV resistance, the rt
Characterization of antiviral resistance mutations among the Eastern Indian Hepatitis B virus infected population.
Frequency and mutation patterns of resistance in patients with chronic hepatitis B infection treated with nucleos(t)ide analogs in add-on and switch strategies.
Discussion: Accordingly, in our previously published report, we found that rtQ215A/H/
Discussion: Furthermore, rtQ215H/P/S substitutions occur as dominant compensatory mutations in treatment-naive hemodialysis patients infected with HBV genotype D (unpublished data).
Discussion: In the current study, we found 1 patient with dual ADV (rtN236T + rtQ215H) and LAM (rtM204V + rtL180M + rtV173L) resistance, detected in different serum samples from the same patient.
Variable influence of mutational patterns in reverse-transcriptase domain on replication capacity of hepatitis B virus isolates from antiviral-experienced patients.
PMID: 21056552
2011
Clinica chimica acta; international journal of clinical chemistry
ViMRT
HBV mutation literature information.
PMID: 
2018
PloS one
