literature

HBV mutation literature information.

Occult HBV infection in Chinese blood donors: role of N-glycosylation mutations and amino acid substitutions in S protein transmembrane domains.

PMID: 31516090 2019 Emerging microbes & infections

Result: Mutations Q16R, Q181R and W182R did not substantially modify the total HBsAg production pattern in M88 and P38.II plasmids (Figure 4).

Result: Seven OBI-specific substitutions introducing an arginine residue in S TMDs were investigated: Q16R in TMD1, C85R, L87R, L88R, and C90R in TMD2, and Q181R and W182R in TMD3.

Discussion: The substitutions Q181R and W182R had no significant impact on HBsAg production pa

Clinical features and viral quasispecies characteristics associated with infection by the hepatitis B virus G145R immune escape mutant.

PMID: 28325923 2017 Emerging microbes & infections

Abstract: Moreover, the frequencies of mutations (L173P, Q181R and A184V) in cytotoxic T lymphocyte epitopes increased before entecavir treatment.

Result: As shown in Supplementary Figure S1, the frequencies of mutations (L173P, Q181R and A184V) in cytotoxic T lymphocyte (CTL) epitopes were increased before entecavir treatment, whereas mutations in the CTL domain aa 44-59 unexpectedly increased after entecavir treatment.

Result: The frequencies of four mutations in the S region (G145R, K160R, L173P and Q181R), four mutations in the RT region (

A new vaccine escape mutant of hepatitis B virus causes occult infection.

PMID: 25692622 2015 Human vaccines & immunotherapeutics

Abstract: Three new mutations (S171F, S174N and Q181R) at the antigenic epitopes of HBV presented by HLA class I molecules are found.

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