Introduction: G145R mutation was the first identified VEMs to be described in 1990, and later several other notable VEMs (I/T126S, Q129H, G130N, D144A, G145A) at different positions associated with HBV breakthrough infections have also been repeatedly documented worldwide.
Result: Eight types of these mutations (I126S, I126N, Q129H, S143L, D144A, D144E, G145A, and G145R) had demonstrated low
Table: Q129H
Genotyping of HBV and tracking of resistance mutations in treatment-naive patients with chronic hepatitis B.
Abstract: In particular, the 'a' determinant surface gene mutations (sT125S, sA128V, sQ129H/R, sT131I, sC137S, sT143M, sD144D/E, sG145R, sT148P) and the majority of clustered/multiple as well as drug selected immune escape HBsAg mutations were more prevalent
HBV genotypes and drug resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected patients.
Method: The sequences were examined for known vaccine escape mutations (sG145R/A, sP142S, s Result: Vaccine escape mutations were found in 7 (11.1%) patients including 040N (sG145R), 159N (sQ129H), 007N (sQ129R), 054N (sD144A), 127E (sD144E), 006N (sD144E), and 119E (sD144E).
Hepatitis B Immunoprophylactic Failure and Characteristics of the Hepatitis B Virus Gene in Mother-Infant Pairs in Parts of China.
PMID: 27998385
2016
Biomedical and environmental sciences
Abstract: The frequency of amino acid mutation of the 'a' determinant region was 16.67% (5/30), including that of Q129H, F134Y, S136Y, and G145E.
Genotyping and Mutation Pattern in the Overlapping MHR Region of HBV Isolates in Southern Khorasan, Eastern Iran.
Abstract: The most amino acid substitutions of surface
Table: Q129H
Discussion: The Q129H was the most frequently detected escape mutant in this study (34.42%), followed by P127L/T (3.27%) and E164D, S117G/T, D144E, T125M, S143L, 1.63% for each; and their roles in the vaccine escape, Ig response and/or detection have already been established.
Discussion: The most prevalent escape mutation among the vaccinated was Q129H/P (6 cases), and S117G, P127L one case for each, while other escape mutations occurred just in the unvaccinated populations.
Serologic and genotypic characterization of hepatitis B virus in HIV-1 infected patients from South West and Littoral Regions of Cameroon.
Abstract: Escape mutations associated with failure of diagnosis (Y100C, R122K and Q129H) and with vaccine escape (Q129R and T131N) were detected in varying frequencies in the population.
Table: Q129H
Discussion: There were three escape mutations identified which were previously associated with diagnostic failure (Y100C, R122K and Q129H) and two associated with vaccine escape (Q129H and T131N).
Occult HBV infection in HCC and cirrhotic tissue of HBsAg-negative patients: a virological and clinical study.
Result: The following AA substitutions and deletions were observed: a) G44E, I92T, Q129H, N59T, and I110L AA substitutions in the S region; b) AA deletions in position 128-131 and G91A, I255T, S98T, N310D, T114I, and T119P AA substitutions in the pre-S1 region; c) AA deletions in position 19-22 and G99E, I147T, F75S, Q184H, H114T and I165L
Serologic and molecular characteristics of hepatitis B virus infection in vaccinated schizophrenia patients in China.
PMID: 27131009
2016
Journal of infection in developing countries
Abstract: Moreover, one HBV strain in the schizophrenia group presented I126S vaccine escape mutation (5.88%), while three HBV isolates showed Q129H, M133L, and G145R vaccine escape mutations in the control group (6.81%).
Ultradeep Sequencing for Detection of Quasispecies Variants in the Major Hydrophilic Region of Hepatitis B Virus in Indonesian Patients.
PMID: 26202119
2015
Journal of clinical microbiology
Abstract: The most frequent MHR variants related to immune evasion in the major and intermediate populations were P120Q/T, T123A, P127T, Q129H/R, M133L/T, and G145R.
HBV mutation literature information.
PMID: 
2017
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