Discussion: The MHR region contains residues 99-169 of HBsAg and T/I126S, Q129H, G130N, S143L, D144A, G145A, and G145R were among the commonly reported mutations.
"Construction and expression of hepatitis B surface antigen escape variants within the ""a"" determinant by site directed mutagenesis."
1Abstract: RESULTS: Ten HBsAg mutants having single mutation within the ""a"" determinant including P120E, T123N, Q129H, M133L, K141E, P142S, D144A, G145R, N146S and C147S together with a wt form were successfully constructed and expressed in CHO cells."
Occult hepatitis B virus infection in anti-HBs-positive infants born to HBsAg-positive mothers in China.
Discussion: Other common escape mutations, including G145R, D144A, P142S, Q129H, I/T126N/A and M133L, were not found in our OBI isolates.
Molecular characterisation of hepatitis B virus in the resident Chinese population in Panama City.
PMID: 23903967
2013
Memorias do Instituto Oswaldo Cruz
Result: The analysis of the MHR mutations revealed a change in residue Q129H in two samples (11%).
Discussion: The substitution Q129H was observed in one sample; this residue has been reported as capable of reducing serological detection in some diagnostic assays.
[The panels of serums, containing various subtypes and mutant forms of HBsAg, to evaluate the diagnostics sensitivity of kits oa reagents detecting HBsAg].
Abstract: The testing of reagents kits to detect HBsAg using twi panels containing recombinant and native variants of HBsAg, demonstrated that these kits enable to detect various sero-vatriants of HBsAg (ayw2, adw2, ayw3varA, ayw3varB, adrq-) in concentration 0.1-0.01 IU/l and the so called elusive mutant forms of HBsAg of recombinant and native origin (G145R, Q129R, Q129H, Q129L, T143K, T126N, T126S, D144A, M133L, K141E and P142S).
Genotyping and molecular characterization of hepatitis B virus from human immunodeficiency virus-infected individuals in southern Africa.
Abstract: The following mutations occurred significantly more frequently in HBV isolated in this study than in strains of the same cluster of the phylogenetic tree: ps1F25L, ps1V88L/A; ps2Q10R, ps2 R48K/T, ps2A53V and sQ129R/H, sQ164A/V/G/D, sV168A and sS174N (p<0.05).
Result: The following mutations occurred signif
Hepatitis B surface antigen variants in voluntary blood donors in Nanjing, China.
Abstract: Eight important mutations associated with diagnostic failure, P120T, T126S, Q129H, G130N, S143L, D144A, and G145A/R, were prevalent in one or more genotypes, with the frequency of no less than 1%.
HBV mutation literature information.
PMID: 
2015
Journal of clinical virology
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