Abstract: Important mutations in surface protein and reverse transcriptase were sI92T, sQ129H, rtL80I, rtS85F, rtL91I.
Substantial variation in the hepatitis B surface antigen (HBsAg) in hepatitis B virus (HBV)-positive patients from South Africa: Reliable detection of HBV by the Elecsys HBsAg II assay.
Abstract: All occult HBV infection-associated Y100C and common diagnostic and vaccine-escape-associated P120T, G145R, K122R, M133L, M133T, Q129H, G130N, and T126S mutations were reliably detected by the assay, which consistently detected the presence of HBsAg in all 179 samples including samples with 11 novel mutations.
Hepatitis B infection among HIV infected individuals in Gabon: Occult hepatitis B enhances HBV DNA prevalence.
Method: In addition, we looked for Vaccine Escape Mutants (VEMs) and polymorphic mutations outside (Y100C, Q101H, S117N, T118R and P120S) and within the HBsAg immuno-dominant 'a' determinant (I/T126A/N, A128V, Q129H/R, G130N, M133L/T, K141E, S143L, D144A/H/E and G145R).
Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.
Result: In addition, several variants in the immunodominant loop of surface protein, including sT118K, sQ129H, and sG145R substitutions in the Discussion: Indeed, sE2G, sL77R, sL98V, sT118K, sQ129H, and sG145R, all of which cause reduced virion secretion, were found in the sera from 9 of 24 (38%) patients with HBV reactivation.
Quasispecies characters of hepatitis B virus in immunoprophylaxis failure infants.
PMID: 29629487
2018
European journal of clinical microbiology & infectious diseases
Abstract: In our data, the substitution rate of amino acid located at a determinant is relatively low (< 10%), I/T126A, C124S, F134Y, K141Q, Q129H, D144A, G145V, and N146K, which showed no statistical difference to their mothers, proving that these vaccine escape mutants preexist maternally as minor variants.
Genotyping of HBV and tracking of resistance mutations in treatment-naive patients with chronic hepatitis B.
Introduction: G145R mutation was the first identified VEMs to be described in 1990, and later several other notable VEMs (I/T126S, Q129H, G130N, D144A, G145A) at different positions associated with HBV breakthrough infections have also been repeatedly documented worldwide.
Result: Eight types of these mutations (I126S, I126N, Q129H, S143L, D144A, D144E, G145A, and G145R) had demonstrated low
Table: Q129H
Molecular characterization of hepatitis B virus in Vietnam.
4Method: The S gene sequence was analyzed for mutations in the ""a"" determinant region (T116 N, P120S/T, I/T126S/A, Q129H/R, M133 L/T, K141E, P142S, D144E, and G145R), and other virulence associated mutations (N3S, V184A, and S204R)."
HBV mutation literature information.
PMID: 
2019
Journal of medical virology
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