8Discussion: Several other studies reported other substitutions in the ""a"" determinant region and associated with vaccine escape, such as T116N, P120S/E, I/T126A/N/I/S, Q129H/R, M133L,
Discussion: Ma and Wang reported that eight mutations (P120T, T126S, Q129H, G130N, S143L, D144A, and G145A/R) are associated with diagnostic failure and mutations in the positions 120, 126, 129, 130, 133, 134, 137, 140, 143, 144, and 145 are recorded in escape variants hat evade vaccine or immunoglobulin therapy.
Detection of Q129H Immune Escape Mutation in Apparently Healthy Hepatitis B Virus Carriers in Southwestern Nigeria.
Discussion: Different studies report the presence of the Q129H mutation in different HBV genotypes, including genotype E, whereas the escape mutation Q129R has been detected in genotypes A, C, and D and Q129L in genotype F only.
Discussion: However, the detection of Q129H among pregnant women and prospective blood donors detected in this study calls for more studies on its transmissibility, other likely effects on its carriers, as well as its interaction with the existing HBV vaccine, in order to prevent its further spread.
Discussion: In both studies other IEMs were also detected; ho
Discussion: In this study, the sQ129H mutation was detected in sequences of 18.2% (n = 8/44) of HBV-positive individuals, which is the highest IEM prevalence reported so far in Nigeria.
Global prevalence and phylogeny of hepatitis B virus (HBV) drug and vaccine resistance mutations.
Result: M133I/L/T and Q129H/N/R had the highest prevalence in genotype B and M133I/L/T had the highest prevalence in Asia, also being present in >3% of the sequences (Figure 2B and 2C).
Result: Other VEMs that had an overall prevalence of >1% were T118A/R/V, M133I/L/T, A128V, Q129H/N/R, G145A/R, P120S/T and S/T143L/M (Figure 2A).
Molecular characteristics of HBV infection among blood donors tested HBsAg reactive in a single ELISA test in southern China.
Result: In addition, immune escape mutants containing Q129H, T131I/T, G145R, and E164V were also found in these S sequences.
Result: Several mutations associated with the interference of HBsAg detection, such as mutations in the major hydrophilic region (MHR), including Q129H, T131I, M133L/S/T, F134L, T143M, and G145R, and mutations outside the MHR, including Y100C, L175S, and Y103I, were foun
Table: Q129H
In silico functional and structural characterization of hepatitis B virus PreS/S-gene in Iranian patients infected with chronic hepatitis B virus genotype D.
Introduction: Also, mutations may occur in association with either vaccine-induced immune-escape (P120T, K122R, T126S, Q129H, G130N, M133L, and M133T) or in relation to the patients with occult HBV infection (Y100C, C124R, C124Y, K141E, and D144A).
Identification of mutations in the S gene of hepatitis B virus in HIV positive Mexican patients with occult hepatitis B virus infection.
Abstract: Most OBI strains were wild-type HBV, but some substitutions V168A, S174 N, V177A, Q129R/L/H, G145A/R in S region of genotype B (OBIB) and T47K/V/A, Result: Previously reported HBV vaccine escape variants carrying point nucleotide mutations in the MHR (aa 124-147) of genotype B were also identified including T116 N (4.3%), P120S (4.3%), T126A (8.7%), Q129R/H (17.3%), D144A/E (8.7%) and G145A/R (21.7%).
HBV mutation literature information.
PMID: 
2021
Infection and drug resistance
Browser Board
Co-occurred Entities
Filtrator
ViMRT