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 HBV mutation literature information.


  Novel hepatitis B virus surface antigen mutations associated with occult genotype B hepatitis B virus infection affect HBsAg detection.
 PMID: 32336003       2020       Journal of viral hepatitis
Abstract: Ten occult infection-related mutations (E2G, Q101R, K122R, M133T, D144E, G145R, V168A, S174N, L175S and I226S) were significantly more frequent in the occult infection group (P < .05).


  Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations.
 PMID: 32994690       2020       World journal of gastroenterology
Abstract: In particular, these mutations were sQ101H/K/R, sS114A/L/T, sT118A/K/M/R/S/V, sP120A/L/Q/S/T, sT/I126A/N/P/S, sM133I/L/T, sC137W/Y, sG145A/R, and sA159G/V.
Result: In particular, mutations were detected in 67/63


  Nearly half of Ultrio plus NAT non-discriminated reactive blood donors were identified as occult HBV infection in South China.
 PMID: 31269905       2019       BMC infectious diseases
Abstract: Most OBI strains were wild-type HBV, but some substitutions V168A, S174 N, V177A, Q129R/L/H, G145A/R in S region of genotype B (OBIB) and T47K/V/A, P49H/L, Q101R/H/K, S174 N, L175S, V177A, T118 M/R/K, G145R/A/K/E, R160K/N in S region of genotype C (OBIC) strains were identified in high frequency.
D


  Prevalence of S gene mutations within the major hydrophilic region of hepatitis B virus in patients in Dongguan, southern China.
 PMID: 28600703       2017       Archives of virology
Abstract: Furthermore, the mutations sY100C, sQ101R/K, sS114A, sP120T, sT/I126A/N/S, sQ129R, sM133L/T/S and sG145R/A were prevalent in at least one genotype, with a frequency higher than 1%, which indicated that these mutations were relatively common.
Abstract: In addition, sQ101K/R was found only in genotype


  Molecular characterization of HBV strains circulating among the treatment-naive HIV/HBV co-infected patients of eastern India.
 PMID: 24587360       2014       PloS one
Result: In addition, other mutations such as Y100D, Q101R/H, M103V/I, D144E and G145S was also found within the major hydrophilic loop (MHL) of the S gene.
Discussion: Several amino acid substitutions within the major hydrophilic loop were observed in our study population which included Y100D, Q101R/H, M103V/I, T125M, A128V, M133L, D144E and G145S.


  Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection.
 PMID: 22086128       2012       Antiviral research
Abstract: Mutants (obtained by site-directed mutagenesis) carrying T116N, T116N+S143L, R122P, R122P+Q101R, or R122P+S167L strongly decreased HBsAg-reactivity (54.9+-22.6S/CO, 31.2+-12.0S/CO, 6.1+-2.4S/CO, 3.0+-1.0S/CO and 3.9+-1.3S/CO, respectively) compared to wild-type (306.8+-64.1S/CO).


  Hepatitis B surface antigen variants in voluntary blood donors in Nanjing, China.
 PMID: 22500577       2012       Virology journal
Result: D99N, Q101R/H, L109I, I110N, T115S, S117T, P120S, K122R, S126T/A, P127H, A128V, Q129R/H/L, G130E, T131N/A, M133T/L/S, F134R/I/L, T143M, A159V, F161Y, W163G, E164G, V168A



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