literature

HBV mutation literature information.

Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.

PMID: 35390033 2022 PloS one

Discussion: (2017) had stated that P203Q and the combination of P203R and S210R hampered the HBsAg secretion and increased cellular proliferation.

Discussion: The correlation of the C-terminus P203Q (17.4% vs 1.0%, p = 0.004), S210R (34.8% vs 3.8%, p<0.001) and of their combination with HCC had been reported in genotype A and D CHB patients.

Effect of hepatitis B virus (HBV) surface-gene variability on markers of replication during treated human immunodeficiency virus-HBV infection in Western Africa.

PMID: 30257068 2019 Liver international

Abstract: Twelve S-gene MUPIQHs were identified among 21 patients (28.8%): sS140L (n = 4), sD144A (n = 1), sS167L (n = 2), sS174N (n = 6), sP178Q (n = 2), sG185L (n = 2), sW191L (n = 2), sP203Q/R (n = 2), sS204N/I/R/K/T/G (n = 7), sN207T

Novel HBsAg mutations correlate with hepatocellular carcinoma, hamper HBsAg secretion and promote cell proliferation in vitro.

PMID: 28152517 2017 Oncotarget

Result: The next step of this study was to investigate the impact of sP203Q, sS210R and sP203Q+sS210R on HBsAg release.|m

Figure: The histogram reports the prevalence of sP203Q, sS210R, and sP203Q+sS210R in 23 HBV-induced HCC patients and in 105 chronically HBV-infected patients (CHB patients) (used as reference group)

Subgenotypes and mutations in the s and polymerase genes of hepatitis B virus carriers in the West Bank, palestine.

PMID: 25503289 2014 PloS one

Table: P203Q

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