HBsAg mutations related to occult hepatitis B virus infection in HIV-positive patients result in a reduced secretion and conformational changes of HBsAg.
1Abstract: We generated a series of expression constructs of variant HBsAg with ""a"" determinant amino acid substitutions including P127L, P127T, S136Y, and P127T + S136Y using site-directed mutagenesis."
Characterization of Novel Hepatitis B Virus PreS/S-Gene Mutations in a Patient with Occult Hepatitis B Virus Infection.
Abstract: The most amino acid substitutions of surface protein were Q129H (34.42%) and A168V (8.2%), other escape mutants observed in this study were P127L/T, S117G, T125M, S143L, D14
Discussion: The Q129H was the most frequently detected escape mutant in this study (34.42%), followed by P127L/T (3.27%) and E164D, S117G/T, D144E, T125M, S143L, 1.63% for each; and their roles in the vaccine escape, Ig response and/or detection have already been established.
Molecular epidemiology of hepatitis B virus isolated from Bangladesh.
Abstract: A significant number of mutations (Thr118Val, Thr125Met, Thr126Ile, Pro127Thr, Ala128Val, Thr131Asn/Ser, Thr/Ser143Leu/Met) were found in ' Discussion: Among which, Thr118Val, Thr125Met, Pro127Thr, Ala128Val and Thr/Ser143Leu/Met were observed in genotype D sequences, which is thought to have strong impacts on functions of S gene.
Discussion: For example, substitution Pro127Thr has been alarmed as great public health significance.
Prevalence of mutations within major hydrophilic region of hepatitis B virus and their correlation with genotypes among chronically infected patients in Egypt.
PMID: 27055927
2016
Arab journal of gastroenterology
Abstract: The first loop comprised four patients with three mutations (P127S, P127T and Y134F).
Characterization of hepatitis B virus surface antigen variability and impact on HBs antigen clearance under nucleos(t)ide analogue therapy.
Abstract: The sT125M+sP127T combination was observed in four nonresolvers of six, corroborated by aa covariance analysis, associated with a lower predicted antigenicity than sT125T+sP127P.
Hepatitis B surface gene variants isolated from blood donors with overt and occult HBV infection in north eastern Egypt.
Result: The most frequent one was Q129R in 4 (40 %) of the retrieved sequences, followed by T125M in 2 (20 %) and P127T in one (10 %) sample.
Result: The most frequent one was Q129R in 40 % (4/10) of the retrieved sequences, followed by T125M in 20 % and P127T in one sample.
Table: P127T
Ultradeep Sequencing for Detection of Quasispecies Variants in the Major Hydrophilic Region of Hepatitis B Virus in Indonesian Patients.
PMID: 26202119
2015
Journal of clinical microbiology
Abstract: The most frequent MHR variants related to immune evasion in the major and intermediate populations were P120Q/T, T123A, P127T, Q129H/R, M133L/T, and G145R.
Single-nucleotide substitution of Hepatitis B virus in intrauterine infection.
Abstract: Most of the mutations were synonymous in pre-S1/S2/S region, while mutations of C2990T, T3205A, A167G, C407A, A667T and A680C resulted in amino acid substitution of A90V, S162T, T47A, P127T, L213F and I218L, respectively.
Molecular epidemiology and genotyping of hepatitis B virus of HBsAg-positive patients in Oman.
HBV mutation literature information.
PMID: 
2017
Journal of medical virology
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