Discussion: In Turkey, the most frequent mutations observed were T143M and K122R, whereas in Egypt 14.8% presented with mutations in the MHR, and eight different mutations were discovered: R122K, S143L, L109P, S114P, S117N, P127S, P127T and Y134F.
Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.
HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy.
5Result: Notably, 9 out of the 10 substitutions resided in the known B- and T-cell epitopes of HBsAg that included 4 substitutions (sT126I, sP127T, sN131T and sN143S) within the ""a""-deter
Discussion: Of these, sI195M and sW196L had been shown to have reduced binding to anti-HBsAg antibodies while a decrease in the antigenicity of the S protein due to the presence of sP127T mutations had been documented.
HBsAg mutations related to occult hepatitis B virus infection in HIV-positive patients result in a reduced secretion and conformational changes of HBsAg.
1Abstract: We generated a series of expression constructs of variant HBsAg with ""a"" determinant amino acid substitutions including P127L, P127T, S136Y, and P127T + S136Y using site-directed mutagenesis."
Temporal trend of hepatitis B surface mutations in the post-immunization period: 9 years of surveillance (2005-2013) in eastern China.
Result: In addition, the other six mutations types (P127T, A128V, G130E, T131P, M133I and D144N) were not yet identified as VEMs, and D144N was a newly identified mutation (Table 3).
Table: P127T
Discussion: Additionally, a small amount of P127T, A128V, G130E, T131P/N, M133T/I, F134L and D144N mutations was observed in our study, including the less frequent T131N/M133T doubl
HBV mutation literature information.
PMID: 
2022
PloS one
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