Abstract: Furthermore, the mutations sY100C, sQ101R/K, sS114A, sP120T, sT/I126A/N/S, sQ129R, sM133L/T/S and sG145R/A were prevalent in at least one genotype, with a frequency higher than 1%, which indicated that these mutations were relatively common.
Characteristics of escape mutations from occult hepatitis B virus infected patients with hematological malignancies in South Egypt.
Abstract: CONCLUSION: Occult HBV infection is common in patients with hematological malignancies and associated with P120T and S143L mutations.
Abstract: The complete HBV genome was retrieved from 6 occult HBV patients, and P120T and S143L were detected in 3 and 2 cases, respectively.
Method: For site-directed mutagenesis, plasmid D-IND 60 was digested by HindIII and EcoO65I, and ligated with the fragments carrying P120T and S143L amino acid mutations to produce the 1.24-fold HBV genome.
Result: As shown in Figure 2A, a lower concentration of HBsAg was detected in the supernatant of Huh7 cells transfected with the P120T variant compared with
Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy.
Result: Other mutations, especially those related to LAM or ETV resistance (rtL180M and rtM204V/I) and classical immune escape (sG145R and/or P120T) variants were noted at no or very low frequencies (Table 1), despite ETV treatment.
Sequence analysis and functional characterization of full-length hepatitis B virus genomes from Korean cirrhotic patients with or without liver cancer.
Abstract: Except for the combination of sP120T+sA128V, other double combinations (n=11) were only detected in the NA treatment group, and nine of these combinations in the treatment group were detected in HBV variants without antiviral resistance mutations.
Investigation of a Novel Hepatitis B Virus Surface Antigen (HBsAg) Escape Mutant Affecting Immunogenicity.
Discussion: Natural mutation at the residue position 120 is very common, and has also been identified in patients with OBI, but the replacement of proline at this position (P120) with threonine (P120T) has been reported to have no effect on HBsAg antigenicity.
Discussion: They also found reduced reactivity of HBsAg mutated at two positions simultaneously (Y100C/P120T).
Genotyping and Mutation Pattern in the Overlapping MHR Region of HBV Isolates in Southern Khorasan, Eastern Iran.
Discussion: Avellon reported M133T (2.2%), Q129H, M133I, F/Y134N (1.8%), F/Y134L, G145A (1.5%), and P120T (1.1%) as the most frequent mutations of S region, while G145R was found at a frequency of less than 1% (0.4%), while among them just Q129H was found in the current study.
Discussion: In another study in Iran, P120T/S and R122K/T were found in 4% of patients, and G145R was found only in one case; which none of them occurred in the current project.
Discussion: The most frequently identified PMID: 26899956
2016
International journal of infectious diseases
Abstract: Amino acid substitutions found in HBV sequences obtained here included P120T, S143L, G145A and A194T.
Broad Range of Hepatitis B Virus (HBV) Patterns, Dual Circulation of Quasi-Subgenotype A3 and HBV/E and Heterogeneous HBV Mutations in HIV-Positive Patients in Gabon.
Abstract: Different amino acid substitutions were identified in overt infection group: S143L/T (16.2 %, 12/74) and P120T/S (2.7 %, 2/74).
Result: The most prevalent variant was S143L/T detected in 12 (16.2 %) of sequences, followed by T115S in 7 (9.5 %), Q129R in 5 (5.8 %), P120T/S in 2 (2.7 %), and K141R in one (1.4 %).
Result: The most prevalent variant was S143L/T detected in 16.2 % of sequences, followed by T115S in 9.5 %, Q129R in 5.8 %, P120T/S in 2.7 %, and K141R in 1.4 %.
ViMRT
HBV mutation literature information.
PMID: 
2017
Archives of virology
