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 HBV mutation literature information.


  Genotyping and molecular characterization of hepatitis B virus from human immunodeficiency virus-infected individuals in southern Africa.
 PMID: 23029487       2012       PloS one
Table: P120T
Discussion: sP120T and sQ129R/H fall within the 'a' determinant and would therefore affect its antigenic ability and infectivity.
Discussion: sP120T, which also leads to an rt128N mutation in the polymerase, has been detected in participants with severe hepatitis following lamivudine (LAM) and HBIg treatment and can partially restore the replicative capacity of LAM-resistant HBV in vitro .


  Hepatitis B genotypes/subgenotypes and MHR variants among Moroccan chronic carriers.
 PMID: 21640384       2011       The Journal of infection
Abstract: The global prevalence of MHR variants was 15% (20/134) with substitution P120T/S the most frequent (3.7%, 5/134).


  Characterization of hepatitis virus B isolated from a multi-drug refractory patient.
 PMID: 20970466       2011       Virus research
Abstract: Three mutations in the surface (S) antigen region, sC76Y, sP120T and sI195M, were detected in 100%, 100% and 77.3% of the clones, respectively.


  Factors associated with vaccine failure and vertical transmission of hepatitis B among a cohort of Canadian mothers and infants.
 PMID: 20546502       2011       Journal of viral hepatitis
Abstract: Of the two cases who were HBeAg negative, one had an undetectable viral load 8 months prior to delivery and a sP120T mutation.


  Diversity of hepatitis B virus infecting Malaysian candidate blood donors is driven by viral and host factors.
 PMID: 20196797       2011       Journal of viral hepatitis
Abstract: HBV vaccine escape substitutions (P120S/T, I126N and G145G) were present in six strains.


  Monitoring of hepatitis B virus surface antigen escape mutations and concomitantly nucleos(t)ide analog resistance mutations in Turkish patients with chronic hepatitis B.
 PMID: 20382061       2010       International journal of infectious diseases
Abstract: In the NUC therapy group the prevalence was 8.5% (12/142), with the following patterns: sY100C+sI110V, sL109I, sP120T, sP127T, sG130R+sG145X, sS132A+sY134N, sY134N+sG145R, s


  Reactivation of hepatitis B virus infection with persistently negative HBsAg on three HBsAg assays in a lymphoma patient undergoing chemotherapy.
 PMID: 20031483       2010       Journal of clinical virology
Abstract: Six amino acid mutations were located in the 'a' determinant, including P120T, K122R, M133T, F134L, D144A and G145A.


  Differential impact of immune escape mutations G145R and P120T on the replication of lamivudine-resistant hepatitis B virus e antigen-positive and -negative strains.
 PMID: 19889778       2010       Journal of virology
Abstract: Although the sP120T substitution also impaired HBsAg secretion, it did not enhance the replication of LAM-resistant clones.
Abstract: However, the concomitant occurrence of HBeAg negativity (PC/BCP), sP120T, and LAM resistance resulted in the restoration of replication to levels of wild-type HBV.
Abstract: Replication-competent HBV strains with sG145R or sP120T and LAM resistance (rtM204I or rtL180M/ PMID: 19301976       2009       The Journal of infectious diseases
Method: Mutations at 10 S envelope protein positions were considered possible vaccine-escape mutations, including sP120T, sI/T126N/A, sQ129H, sM133L, sK141E, sP142S, sD144A, sG145R, sF158Y, and s PMID: 18803358       2008       World journal of gastroenterology
Abstract: In the HBV S region, the genetic variability was low, and the marked substitution was P120T/S, with a rate of 9.7% (n = 6).



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