Ultradeep Sequencing for Detection of Quasispecies Variants in the Major Hydrophilic Region of Hepatitis B Virus in Indonesian Patients.
PMID: 26202119
2015
Journal of clinical microbiology
Abstract: The most frequent MHR variants related to immune evasion in the major and intermediate populations were P120Q/T, T123A, P127T, Q129H/R, M133L/T, and G145R.
Seroepidemiology and occult hepatitis B virus infection in young adults in Banjarmasin, Indonesia.
Abstract: Thirteen amino acid substitutions were identified: T126S, P127S, Q129R, T131N, M133T, and Y161S in the HBsAg-positive group; P120T, T126I, G145S, Y161F, E164V, and V168F in the occult-HBV group; and T143S in both groups.
Occult hepatitis B infection among individuals belonging to the aboriginal Nicobarese tribe of India.
PMID: 25500663
2014
Journal of infection in developing countries
Abstract: Single or multiple amino acids substitutions were found in 5 of 34 samples (14.7%) which includes I110T, P120T, P/T127I, A128P, M133L and G159V.
Occult hepatitis B virus infection among blood donors in Colombia.
Discussion: Thirteen MHR mutations (G119R, P120T, C124R, C124Y, I126S, Q129R, S136P, C139R, T140I, K141E, D144A, G145A, and G145R) were detected and functionally characterized in vitro and in vivo.
Molecular epidemiology and genotyping of hepatitis B virus of HBsAg-positive patients in Oman.
Abstract: Two patients showed the described HBV vaccine escape mutation sP120T.
Result: However, the well-described vaccine escape mutation P120T was found in two sequences of HBsAg-positive patients (samples 43 and 88) while both of them could be related to HBV genotype D.
Table: P120T
Discussion: Of the 170 HBV isolates analyzed, 148 (87.06%) showed wild-type sequences and only 22 (12.94%) revealed mutations in the HBsAg gene and of these two isolates (1.1%) showed the described vaccine escape mutation sP120T.
Discussion: Of these, the well-characterized sP120T mutation could be detected in 2/170 PMID: 24165277
2013
Virology journal
Abstract: The mutations detected were as follows: sM133L + sI195T (2.94%), sI195M (2.94%), sP120T (2.94%), sY100S/F (2.94%), sY100C (17.64%), sI/T126P + sQ129P (2.94%), sM198I + sF183C (2.94%) and sS210R (5.88%).
Result:
Mutations in the S gene region of hepatitis B virus genotype D in Golestan Province-Iran.
Abstract: Eight important mutations associated with diagnostic failure, P120T, T126S, Q129H, G130N, S143L, D144A, and G145A/R, were prevalent in one or more genotypes, with the frequency of no less than 1%.
A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.
Abstract: In the immunodominant 'a' region of the surface gene, point mutations were identified in 31% (n = 58/187) of sequences, and 2.2% (n = 4/187) and 5.3% (n = 10/187) specimens contained the major vaccine escape mutations G145A/R and P120L/Q/S/T, respectively.
Result: Mutations associated with immune escape were identified in 23.5% (n = 45/187) samples and included the following residues Y100C (n = 6), T118K (n = 1), P120L/Q/S/T (n = 10), T123A/N (n = 2), I126N/S (n = 8), P127S (n = 2), Q129R (n = 2), G130D/N/R (n = 1),
Hepatitis B virus gene mutations in liver diseases: a report from New Delhi.
Result: Amino acid mapping reveals that the S region was relatively conserved; however, an important substitution of P120T/S was observed in 7.8% (9/115) of AVH and 11.2% (13/116) in CH patients.
Discussion: As previously reported, the P120T/S substitution may cause problems with diagnostic assays, and may also cause vaccine escape and poor response to HBIG therapy.
Discussion: In this study, the P120T/S was the most important substitution.
Discussion: The P120T/S was detected in 7.8% of chronic hepatitis and 11.2% in patients with cirrhosis.
HBV mutation literature information.
PMID: 
2015
Journal of clinical microbiology
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