literature

HBV mutation literature information.

Association of HBsAg mutation patterns with hepatitis B infection outcome: Asymptomatic carriers versus HCC/cirrhotic patients.

PMID: 31105017 2019 Annals of hepatology

Abstract: However, Y134N/F/L (P=0.04) and P120T/S (P=0.009) were significantly detected in MHR and B-cell epitope of HCC/Cirrhotic group.

Patterns of hepatitis B virus S gene escape mutants and reverse transcriptase mutations among genotype D isolates in Jordan.

PMID: 30867996 2019 PeerJ

Discussion: This is comparable to a study done in Iran, which showed that the frequency of 14% major hydrophilic region mutations (MHR), with the most frequent ones of P120T/S and R122K/T.

Viral quasispecies of hepatitis B virus in patients with YMDD mutation and lamivudine resistance may not predict the efficacy of lamivudine/adefovir rescue therapy.

PMID: 30906435 2019 Experimental and therapeutic medicine

Discussion: sP120T and sG145R) that may be associated with LAM resistance, were not detected in the present study.

Evaluation of the pol/S Gene Overlapping Mutations in Chronic Hepatitis B Patients in Northern Cyprus.

PMID: 31880877 2019 Polish journal of microbiology

Result: The mutation patterns were sI110L + sS193L, sP120L + + sT123N + sT126I + sA128V + sY134H + sD144E + +sG145A, sT118A+sP127T, sI110L+

Molecular Epidemiology of Hepatitis B Virus in Turkish Cypriot.

PMID: 31880889 2019 Polish journal of microbiology

Table: P120T

Substantial variation in the hepatitis B surface antigen (HBsAg) in hepatitis B virus (HBV)-positive patients from South Africa: Reliable detection of HBV by the Elecsys HBsAg II assay.

PMID: 29414186 2018 Journal of clinical virology

Abstract: All occult HBV infection-associated Y100C and common diagnostic and vaccine-escape-associated P120T, G145R, K122R, M133L, M133T, Q129H, G130N, and T126S mutations were reliably detected by the assay, which consistently detected the presence of HBsAg in all 179 samples including samples with 11 novel mutations.

Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.

PMID: 29408943 2018 PloS one

Table: P120T

Immune-escape mutations and stop-codons in HBsAg develop in a large proportion of patients with chronic HBV infection exposed to anti-HBV drugs in Europe.

PMID: 29859062 2018 BMC infectious diseases

Abstract: Strong correlation was observed between sP120T and rtM204I/V (P < 0.001), and their co-presence determined an increased HBV-DNA.

Method: Among them, sP120S/T/A, sT126N/S, sQ129R/N, sT131I/N, sM133I/L, sP142S, sD144A/E, sG145A/R were kn

Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy.

PMID: 28392234 2017 Journal of hepatology

Result: Other mutations, especially those related to LAM or ETV resistance (rtL180M and rtM204V/I) and classical immune escape (sG145R and/or P120T) variants were noted at no or very low frequencies (Table 1), despite ETV treatment.

Investigation of a Novel Hepatitis B Virus Surface Antigen (HBsAg) Escape Mutant Affecting Immunogenicity.

PMID: 28045894 2017 PloS one

Discussion: Natural mutation at the residue position 120 is very common, and has also been identified in patients with OBI, but the replacement of proline at this position (P120) with threonine (P120T) has been reported to have no effect on HBsAg antigenicity.

Discussion: They also found reduced reactivity of HBsAg mutated at two positions simultaneously (Y100C/P120T).

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