literature

HBV mutation literature information.

Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.

PMID: 35390033 2022 PloS one

Discussion: (2019) had previously found the higher rate of P120T/S in HCC with cirrhosis group.

Discussion: Regarding to the OR values of mutations on the final multivariable analysis, 2 S mutations including 23 cases of T47A/E/V/K (S) and 21 cases of P120S/T (S) had revealed three folds increase in HCC risk associated with reasonable confidential intervals.

Discussion: The final findings had recognized 5 mutations (W4P/R/Y on the PreS1 region and T47A/E/V/K,

Prevalence, genotype distribution and mutations of hepatitis B virus and the associated risk factors among pregnant women residing in the northern shores of Persian Gulf, Iran.

PMID: 35271684 2022 PloS one

Discussion: P120T and G145R mutations in the S gene are associated with low responses to HBV vaccination and immunoglobulin therapy as well as failures of diagnostic tests.

Discussion: Nevertheless, P120T and G145R mutations associated with failure of HBsAg detection were not found in this sample.

Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.

PMID: 35214692 2022 Vaccines

Introduction: Across different genotypes, the most frequent substitutions were I/T126S (1.8%), G145R (1.2%), M133T (1.2%), Q129R (1.0%), I/T126A (0.8%), and P120T (0.8%).

Introduction: These major mutations were more common in genotypes A (P120T, 3.2%), B (I/T126A, 2.8%; Q129R, 2.2%), C (I/T 126S, 3.9%; M133T, 1.9%), and G (G145R, 5.0%).

Characterization of Antigen Escape Mutations in Chronic HBV-Infected Patients in Upper Egypt.

PMID: 34234472 2021 Infection and drug resistance

Abstract: The observed mutations were T115S (3/20, 15%), P120T/S (3/20, 15%), T126S (1/20, 5%), Q129R (2/20, 10%), M133T (2/20, 10%), S143L (5/20, 25%), D144E/A (3/20, 15%), and G145R/A (4/20, 20%).

Result: The following mutation pairs were observed: T115S (3/20, 15%), P120T/S (3/20, 15%), T126S (1/20, 5%), Q129R (2/20, 10%), M133T (2/20, 10%), S143L (5/20, 25%), D144E/A (3/20, 15%), and G145R/A

Global prevalence and phylogeny of hepatitis B virus (HBV) drug and vaccine resistance mutations.

PMID: 33893696 2021 Journal of viral hepatitis

Result: Other VEMs that had an overall prevalence of >1% were T118A/R/V, M133I/L/T, A128V, Q129H/N/R, G145A/R, P120S/T and S/T143L/M (Figure 2A).

Case Report: Application of hepatitis B virus (HBV) deep sequencing to distinguish between acute and chronic infection.

PMID: 33458253 2020 Wellcome open research

Table: P120S/T

In silico functional and structural characterization of hepatitis B virus PreS/S-gene in Iranian patients infected with chronic hepatitis B virus genotype D.

PMID: 32695898 2020 Heliyon

Introduction: Also, mutations may occur in association with either vaccine-induced immune-escape (P120T, K122R, T126S, Q129H, G130N, M133L, and M133T) or in relation to the patients with occult HBV infection (Y100C, C124R, C124Y, K141E, and D144A).

"Occult Hepatitis B Virus Infection in Maintenance Hemodialysis Patients: Prevalence and Mutations in ""a"" Determinant."

PMID: 32922195 2020 International journal of medical sciences

8Discussion: According to the reports, the ""a"" determinant of OBI patients contains Gly145Arg/Ala/Ile/Trp/Glu (G145R/A/I/W/E), Leu109Arg (L109R), Gly119Arg (G119R), Pro120Thr (P120T), Lys122Ile (K122I), Thr126Asn (T126N), Thr127Arg (T127R), Gln129Asn (Q129N), Thr131Asn (T131N

Comprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Region.

PMID: 33381105 2020 Frontiers in microbiology

Result: The most common substitutions were I/T126S (1.8%), G145R (1.2%), M133T (1.2%), Q129R (1.0%), I/T126A (0.8%), and P120T (0.8%).

Result: These major mutations were more frequent in genotypes A (P120T, 3.2%), B (I/T126A, 2.8%; Q129R, 2.2%), C (I/T126S, 3.9%; M133T, 1.9%), and G (G145R, 5.0%).

Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations.

PMID: 32994690 2020 World journal of gastroenterology

Abstract: In particular, these mutations were sQ101H/K/R, sS114A/L/T, sT118A/K/M/R/S/V, sP120A/L/Q/S/T, sT/I126A/N/P/S

Discussion: This is supported by a previous study demonstrating that two classical immune escape-associated mutations, sG145R and sP120T, significantly reduce HBsAg production and increase the replication capacity of LAM-resistant HBV mutants.

Browser Board

Co-occurred Entities

Filtrator