Abstract: Mutations in the S region of HBV DNA included S114T, G119R, P120S, T125M, C139Y, T140I,
Result: Variants were found in 30.4% (21/69) of cases with OBI and included S114T, G119R, P120S, T125M, C139Y, T140I, C147W, T148A, A159V/G, E164D, V168A and R169C.
Hepatitis B surface gene variants isolated from blood donors with overt and occult HBV infection in north eastern Egypt.
Abstract: Different amino acid substitutions were identified in overt infection group: S143L/T (16.2 %, 12/74) and P120T/S (2.7 %, 2/74).
Result: The most prevalent variant was S143L/T detected in 12 (16.2 %) of sequences, followed by T115S in 7 (9.5 %), Q129R in 5 (5.8 %), P120T/S in 2 (2.7 %), and K141R
Result: The most prevalent variant was S143L/T detected in 16.2 % of sequences, followed by T115S in 9.5 %, Q129R in 5.8 %, P120T/S in 2.7 %, and K141R in 1.4 %.
Table: P120T/S
Virology and clinical sequelae of long-term antiviral therapy in a North American cohort of hepatitis B virus (HBV)/human immunodeficiency virus type 1 (HIV-1) co-infected patients.
Abstract: Anti-HBV drug resistant mutations were detected in 54% (6/11) (i.e., any combination of rtV173L, rtL180M, M204V) and 45% (5/11) had an immune escape mutation (sP120S).
Characterization of hepatitis B virus genome variability in Iranian patients with chronic infection, a nationwide study.
Result: Amino acid mapping reveals that the S region was relatively conserved; however, an important substitution of P120T/S was observed in 7.8% (9/115) of AVH and 11.2% (13/116) in CH patients.
Discussion: As previously reported, the P120T/S substitution may cause problems with diagnostic assays, and may also cause vaccine escape and poor response to HBIG therapy.
Discussion: In this study, the P120T/S was the most important substitution.
Discussion: The P120T/S was detected in 7.8% of chronic hepatitis and 11.2% in patients with cirrhosis.
A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.
Abstract: In the immunodominant 'a' region of the surface gene, point mutations were identified in 31% (n = 58/187) of sequences, and 2.2% (n = 4/187) and 5.3% (n = 10/187) specimens contained the major vaccine escape mutations G145A/R and P120L/Q/S/T, respectively.
Result: Mutations associated with immune escape were identified in 23.5% (n = 45/187) samples and included the following residues Y100C (n = 6), T118K (n = 1), P120L/Q/S/T (n = 10), T123A/N (n = 2), I126N/S (n = 8), P127S (n = 2), Q129R (n = 2), G130D/N/R (n = 1),
Hepatitis B surface antigen variants in voluntary blood donors in Nanjing, China.
HBV mutation literature information.
PMID: 
2016
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