Hepatitis B virus reactivation sustained by a hepatitis B virus surface antigen immune-escape mutant isolate in a patient who was hepatitis B core antibody positive during treatment with sofosbuvir and velpatasvir for hepatitis C virus infection: a case report.
PMID: 31542053
2019
Journal of medical case reports
Abstract: Sequencing analysis revealed the hepatitis B virus genotype D3 and the presence of two relevant immune-escape mutations (P120S and T126I) in the major hydrophilic region by analyzing the S region.
Conclusion: In contrast, by analyzing the S region, two relevant mutations, P120S and T126I, localized in the major hydrophilic region, an immune-active HBsAg domain, were found.
Deep sequencing of hepatitis B surface antigen gene in the preserved umbilical cords in immunoprophylaxis failure against mother-to-child HBV transmission.
Method: In addition, we looked for Vaccine Escape Mutants (VEMs) and polymorphic mutations outside (Y100C, Q101H, S117N, T118R and P120S) and within the HBsAg immuno-dominant 'a' determinant (I/T126A/N, A128V, Q129H/R, G130N, M133L/T, K141E, S143L, D144A/H/E and G145R).
Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.
Immune-escape mutations and stop-codons in HBsAg develop in a large proportion of patients with chronic HBV infection exposed to anti-HBV drugs in Europe.
Result: This is the case of sA128V and sP120S selected with higher prevalence in genotype-D than A (sA128V: 3.3%[19/573] vs 0.8%[2/255], P = 0.032; sP120S: 5.1%[29/573] vs 0.8[2/255], P = 0.003).
Figure: Immune-associated escape mutations (sQ101K, sT114R, sP120S/T/A, sT123A/N, sT126N/S, s
HBV genotypes and drug resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected patients.
Method: The sequences were examined for known vaccine escape mutations (sG145R/A, sP142S, sI/T126A/N/I/S, sQ129H/R, sM133L, sD144A/E, sP120S/E, sK141E, sP134I, and sT116N), immunoprophylaxis escape mutations (
Characteristics of escape mutations from occult hepatitis B virus infected patients with hematological malignancies in South Egypt.
Result: E1 mutants included P120S (n = 3), P120PS (n = 1), P120PT plus T123TI (n = 1) and T123S (n = 1).
Result: Six strains had mutations exclusively in E1 including changes at P120, which were included with the E1 mutations because the 3 P120S mutants were all classified as E1 mutants in the HBsAg mutant assay.
Result: The nomenclature to specify mutants used here is the one letter code for the wild type amino acid, the amino acid position within HBsAg and the one letter code for the mutant amino acid; for example, P120S designates proline at position 120 changed to serine.
Discussion: The most common mutations were found in E2 at amino acid positions 143, 144, and 145, which have been shown to impact diagnostic assay sensitivity,
Molecular characterization of hepatitis B virus in Vietnam.
4Method: The S gene sequence was analyzed for mutations in the ""a"" determinant region (T116 N, P120S/T, I/T126S/A, Q129H/R, M133 L/T, K141E, P142S, D144E, and G145R), and other virulence associated mutations (N3S,
5Result: Among the isolates, 8.1% (11/135) had a mutation in the ""a"" determinant region including 2.2% (3/135) P120S/T, 2.2% (3/135) I/T126S/A, 3% (4/135) M133 L/T and 0.7% (1/135) G145R."
Genotyping and Mutation Pattern in the Overlapping MHR Region of HBV Isolates in Southern Khorasan, Eastern Iran.
Discussion: In another study in Iran, P120T/S and R122K/T were found in 4% of patients, and G145R was found only in one case; which none of them occurred in the current project.
HBV mutation literature information.
PMID: 
2019
Journal of medical case reports
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