Introduction: (n = 187) had reported a rate of 31% cases with point-mutation in the immunodominant 'a' region, especially two major vaccine escape mutations with minor rates as G145A/R (2.2%) and P120L/Q/S/T (5.3%) had been detected.
Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations.
PMID: 32994690
2020
World journal of gastroenterology
Abstract: In particular, these mutations were sQ101H/K/R, sS114A/L/T, sT118A/K/M/R/S/V, sP120A/L/Q/S/T, sT/I126A/N/P/S, sM133I/L/T, sC137W/Y, sG145A/R, and sA159G/V.
Result: In particular, mutations were detected in 67/63
Patterns of hepatitis B virus S gene escape mutants and reverse transcriptase mutations among genotype D isolates in Jordan.
Introduction: Among other commonly detected vaccine-escape mutants are: P120Q, Q129H, F134Y/L, S143L and D144A/E.
Viral quasispecies of hepatitis B virus in patients with YMDD mutation and lamivudine resistance may not predict the efficacy of lamivudine/adefovir rescue therapy.
PMID: 30906435
2019
Experimental and therapeutic medicine
Result: In the present study, the most prevalent mutations were those in the S region (sP120Q, sQ129R, sT131I, sM133I, sG145R, sY161F/H, sI195M/T, sW196S/L, sW199C/L and sM213I/T; Table III).
Nearly half of Ultrio plus NAT non-discriminated reactive blood donors were identified as occult HBV infection in South China.
Result: P120Q/S (8.7%) and Q129H (4.3%) substitutions were detected and recognized to have a major impact on HBsAg detection, while Y100S (8.7%) substitution was observed responsible in OBIs for lack of excretion of HBsAg.
Result: P120Q (4.3%), T123A (4.3%), I126S, M133 T (8.7%), F134 L (4.3%) substitutions were found which might potentially affect HBsAg detection.
Hepatitis B virus subgenotype F3 reactivation with vaccine escape mutations: A case report and review of the literature.
Abstract: The reactivated virus was HBV genotype F3 with vaccine escape mutations G145R, P120Q, and Q129P.
Discussion: To the best of our knowledge, this is the first case describing breakthrough of HBV genotype F due to G145R, P120Q, and Q129P escape mutations in a transplant setting.
Discussion: We also identified a P120Q mutation in the upstream region of the HBV core gene and two different mutations at positions Q129, Q129P, and H in our patient.
Genetic variability in coding regions of the surface antigen and reverse transcriptase domain of hepatitis B virus polymerase, Colombia, 2002-2014
Introduction: Recently, a novel vaccine escape S gene mutant (sP120Q+sD144A) was described.
Ultradeep Sequencing for Detection of Quasispecies Variants in the Major Hydrophilic Region of Hepatitis B Virus in Indonesian Patients.
PMID: 26202119
2015
Journal of clinical microbiology
Abstract: The most frequent MHR variants related to immune evasion in the major and intermediate populations were P120Q/T, T123A, P127T, Q129H/R, M133L/T, and G145R.
Epidemiology of HBV S-gene mutants in the Liguria Region, Italy: Implications for surveillance and detection of new escape variants.
PMID: 23296324
2013
Human vaccines & immunotherapeutics
Abstract: HBsAg resulted undetectable by 3 of the 8 samples, derived from patients with multiple mutations: T126I-T131A-C139Y-E/D144G, T126I-M133L, and P120Q-T126I.
HBV mutation literature information.
PMID: 
2022
PloS one
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