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 HBV mutation literature information.


  Detection and analysis of resistance mutations of hepatitis B virus.
 PMID: 26309637       2015       International journal of clinical and experimental medicine
Abstract: L180M, M204I and M204V were associated with the resistance to lamivudine and telbivudine; L180M, M204I, M204V and V173L were associated with the resistance to entecavir; A181T, N236T and N/H238T were related to the resistance to adefovir.


  Efficacy of tenofovir disoproxil fumarate therapy in nucleoside-analogue naive Iranian patients treated for chronic hepatitis B.
 PMID: 26045705       2015       Hepatitis monthly
Result: Moreover, a comparison between baseline and post-baseline samples from these patients showed that the presence of rtL91I, rtN238H/T/S, rtC256G, rtN53S/T and rtY54N mutations reduced significantly after the initiation of TD
Table: N238H/T
Discussion: In addition, two mutations of rtL91I and rtN238H/T/S presented in 10% of baseline sequences from patients, were not detected in these patients after the treatment with TDF.


  Molecular characterisation of hepatitis B virus in the resident Chinese population in Panama City.
 PMID: 23903967       2013       Memorias do Instituto Oswaldo Cruz
Result: Two secondary mutations that were potentially associated with resistance, rtV207L and rtN238T, were identified in one (6%) and five (33%) of the analysed samples, respectively.
Discussion: Although primary drug resistance changes in the RT domains studied were completely absent, secondary drug resistance changes in domains C (rtV207L) and D (rtN238T) were identified in one (6%) and five (31%) samples, respectively, which were higher than previous reports, although the study group was small (n = 16) .


  Drug-related mutational patterns in hepatitis B virus (HBV) reverse transcriptase proteins from Iranian treatment-naive chronic HBV patients.
 PMID: 23596461       2013       Hepatitis monthly
Discussion: In addition, a number of other mutations have been detected in our study and were clustered into three distinct regions of the RT: the D and A domains (rtP237H, rtN238T/D, rtV84M, and rtS85A) and the C-D interdomain (rtS213T/N, rtV214A, and rtQ215S).


  Prevalence, virology and antiviral drugs susceptibility of hepatitis B virus rtN238H polymerase mutation from 1865 Chinese patients with chronic hepatitis B.
 PMID: 22138714       2012       Antiviral research
Abstract: Amino acid substitutions at positions rtN238T/D of the hepatitis B virus (HBV) polymerase have been reported as potential mutations associated with adefovir (ADV) resistance.
Abstract: Among 1865 enrolled HBV infected patients, 8.8% (165/1865) showed mutations in the rtN238 locus (143 males/22 females, 91 treatment-naive, 42 ADV-treated, 16 LAM-treated and 16 ADV+LAM-treated), namely 86% rtN238H (142/165), 5.5% rtN238S (9/165), 5.5% rtN238T (9/165) and 3% rtN238D (5/165).


  Hepatitis B virus mutations potentially conferring adefovir/tenofovir resistance in treatment-naive patients.
 PMID: 19222103       2009       World journal of gastroenterology
Abstract: These mutations were rtV214A/rtN238T in one patient and rtA194T in the other.


  [Resistance to adefovir in patients with chronic hepatitis B].
 PMID: 17237626       2006       The Korean journal of hepatology
Abstract: Other mutations in the HBV polymerase (rtP237H, rtN238T/D, rtV84M, rtS85A, rtV214A, rtQ215S) reduce sensitivity to adefovir, but the significance of these mutations is unclear.



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