literature

HBV mutation literature information.

Dried blood spot sampling for hepatitis B virus quantification, sequencing and mutation detection.

PMID: 35102169 2022 Scientific reports

Table: N238T

Hepatitis B in the Northwestern region of Sao Paulo State: genotypes and resistance mutations.

PMID: 34755817 2021 Revista do Instituto de Medicina Tropical de Sao Paulo

Result: One sample (1.1%) presented a compensatory mutation (rtV/F/L/M207I), which typically appears after other primary variants of resistance to LAM; and 26.7% (24/90) of the samples showed pote

Result: Strains with partial resistance mutations for ETV (rtM204V/I/S) or potentially associated with resistance to ADF (rtV214A, rtL217R, rtQ215S, rtN238T, and rtP237H) were identified in 13.9% (5/36) and 19.4% (7/36) of the samples, respectively.

Fast and Sensitive Real-Time PCR Detection of Major Antiviral-Drug Resistance Mutations in Chronic Hepatitis B Patients by Use of a Predesigned Panel of Locked-Nucleic-Acid TaqMan Probes.

PMID: 34319801 2021 Journal of clinical microbiology

Abstract: Single-point mt for LMV and ADF resistance were detected in 57.7% and 54.1% of the child and adult samples, respectively, with rtV207M (children, 42.3%; adults, 36.7%) and rtN238T/A (children, 15.4%; adults, 16.3%) being the most frequent mt in these populations.

Abstract: We developed a novel real-time PCR assay that simultaneously evaluates 11 major nucleos(t)ide antiviral (NA) drug resistance mutations (mt) in chronic hepatitis B patients (CHB), including L180M, M204I/V, and V207M (lamivudine [LMV] resistance), N/H238A/T (adefovir [ADF] resistance), which are circula

COLD-PCR Method for Early Detection of Antiviral Drug-Resistance Mutations in Treatment-Naive Children with Chronic Hepatitis B.

PMID: 32708399 2020 Diagnostics (Basel, Switzerland)

Method: All sequences with completely replaced mt were further determined based on an HBV-drug resistance interpretation online tool of Max Planck Institute for Informatics for classical mt, e.g., rtL180M, rtA181V/T, rtT184G/L, rtA194T, rtS202I/G, rtM204I/V, rtN236T, and rtM250I/V, and based on updated references for nonclassical/putative mt, e.g., V207I/M/L,

Detection of circulating hepatitis B virus immune escape and polymerase mutants among HBV-positive patients attending Institut Pasteur de Bangui, Central African Republic.

PMID: 31682960 2020 International journal of infectious diseases

Result: These included the previously reported mutations rtL91I, rtM129L, rtW153R, rtS213T, rtV214A, rtN238T, rtN248H, and rtI269L (Yamani et al.,; Choi et al.,; Shaha et al.,; Ababneh et al.,).

Discussion: This study identified several known polymerase mutations (rtL91I, rt

Frequency of Hepatitis B Virus Resistance Mutations in Women Using Tenofovir Gel as Pre-Exposure Prophylaxis.

PMID: 31248149 2019 Viruses

Abstract: None of the known tenofovir resistance mutations (M240V/I, L180M, A194T, V214A, N238T) were identified in any individuals.

Characterization and Clinical Significance of Natural Variability in Hepatitis B Virus Reverse Transcriptase in Treatment-Naive Chinese Patients by Sanger Sequencing and Next-Generation Sequencing.

PMID: 31189581 2019 Journal of clinical microbiology

Result: Considering that the low sensitivity of Sanger sequencing limited the detection of NAr mutations with a low rate (<20%), 4 classical drug resistance mutations (S202C/G/I, M204I/V/S, N236T, and M250I/L/V) and 12 putative NAr mutations (V207I, S213T, V214A, Q215P/S, L217R, E218D, L229G/V/W/F, I233V, P237H, N/H238D/S/T, Y245H, and S/C256G)

Potential resistant mutations within HBV reverse transcriptase sequences in nucleos(t)ide analogues-experienced patients with hepatitis B virus infection.

PMID: 31147594 2019 Scientific reports

Table: N238T

Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression.

PMID: 29713126 2018 World journal of gastroenterology

Method: A total of 26 types of RT mutations, including rtS53N, rtT54N, rtL82M, rtV84M, rtS85A, rtI91L, rtY126C, rtT128I/N, rtN139D, rtW153Q, rtF166L, rt

Epidemiology study of HBV genotypes and antiviral drug resistance in multi-ethnic regions from Western China.

PMID: 26612031 2015 Scientific reports

Result: and so did other mutations (rtN/H238T P < 0.001, rtP237H P = 0.002, and rtV214A P = 0.006).

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