Potential resistant mutations within HBV reverse transcriptase sequences in nucleos(t)ide analogues-experienced patients with hepatitis B virus infection.
Result: In case three, multiple mutation patterns were observed from L180M + M204V + I224V + N238H to L180M + M204V + T184S + I224V + N238H under LAM and ADV combined therapy, which developed resistance to ETV.
Table: N238H
Table: N238N/H
Discussion: considered that N238H variant did neither influence the susceptibilities to LAM or ADV nor weak the viral replication efficiency in vitro.
Discussion: proved that N238H mutation had little effect on ETV resistance.
Discussion: reported that single m
Frequency of Hepatitis B Virus Resistance Mutations in Women Using Tenofovir Gel as Pre-Exposure Prophylaxis.
Result: Although the frequency of amino acid substitutions were not significantly different, a total of 16 amino acid substitutions in the polymerase domain occurred only in tenofovir-experienced isolates compared to tenofovir-naive isolates, including S117Y, S117C, I121N, T128I, M129L, R138K, R138E, L140P, V142A, I163V, L217R, N238H, R242K, K270R, V278I, and R280S.
Efficacy of tenofovir disoproxil fumarate therapy in nucleoside-analogue naive Iranian patients treated for chronic hepatitis B.
Result: Moreover, a comparison between baseline and post-baseline samples from these patients showed that the presence of rtL91I, rtN238H/T/S, rtC256G, rtN53S/T and rtY54N mutations reduced significantly after the initiation of TDF treatment (P < 0.05) (Table 4).
Table: Discussion: In addition, two mutations of rtL91I and rtN238H/T/S presented in 10% of baseline sequences from patients, were not detected in these patients after the treatment with TDF.
Prevalence, virology and antiviral drugs susceptibility of hepatitis B virus rtN238H polymerase mutation from 1865 Chinese patients with chronic hepatitis B.
Abstract: Among 1865 enrolled HBV infected patients, 8.8% (165/1865) showed mutations in the rtN238 locus (143 males/22 females, 91 treatment-naive, 42 ADV-treated, 16 LAM-treated and 16 ADV+LAM-treated), namely 86% rtN238H (142/165), 5.5% rtN238S (9/165), 5.5% rtN238T (9/165) and 3% rtN238D (5/165).
Abstract: Among the rtN238H mutant strains, there were no significant differences between ADV- or/and LAM- treated patients and treated-naive patients (42% vs.
Abstract: As rtN238H di
Variable influence of mutational patterns in reverse-transcriptase domain on replication capacity of hepatitis B virus isolates from antiviral-experienced patients.
PMID: 21056552
2011
Clinica chimica acta; international journal of clinical chemistry
Abstract: We also detected several polymorphic sites,including rtF221Y, rtS223A, rtI224V, rtN238H, rtL267Q, and rtQ271M, during the sequential treatment.
HBV mutation literature information.
PMID: 
2019
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