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 HBV mutation literature information.


  Characterization of drug-resistance mutations in HBV D-genotype chronically infected patients, naive to antiviral drugs.
 PMID: 21920388       2011       Antiviral research
Abstract: HBV reverse-transcriptase (RT) region was sequenced and analyzed for 20 mutations, confirmed by in vitro studies as associated with resistance to nucleos(t)ide HBV-RT inhibitors (rtL80I/V-rtI169T-rtV173L-rtL180M-rtA181T/V/S-rtT184A/S/G/C-rtA194T-rtS202C/G/I-


  Emergence of the rtA181T/sW172* mutant increased the risk of hepatoma occurrence in patients with lamivudine-resistant chronic hepatitis B.
 PMID: 21933446       2011       BMC cancer
Introduction: The major ADV resistant mutants were rtN236T and rtA181T/V.


  Virological response to adefovir monotherapy and the risk of adefovir resistance.
 PMID: 21941420       2011       World journal of gastroenterology
Abstract: RESULTS: At week 48 and 96, eight (10%) and 14 (18%) of 77 LAM-resistant patients developed the ADV-resistant strain (rtA181V/T and/or rtN236T mutations), respectively.


  Frequency and mutation patterns of resistance in patients with chronic hepatitis B infection treated with nucleos(t)ide analogs in add-on and switch strategies.
 PMID: 22224083       2011       Hepatitis monthly
Abstract: The most common LAM and ETV resistance mutations were rtM204I/V, rtL180M and rtT184A/I/S, respectively, while rtA181T/V and rtN236T substitutions were the most frequently observed ADV resistance mutations.
Result: N236T) were most frequently detected.
Result: The ADV-associated mutations rtA181T/V, rtN236T, and rtA181T +  PMID: 19550344       2010       European journal of gastroenterology & hepatology
Abstract: In contrast, of the 11 patients treated with ADV, three patients developed mutations (rtN236T; rtA181V; rtA181V plus rtN236T).


  Naturally occurring amino-acid substitutions to nucleos(t)ide analogues in treatment naive Turkish patients with chronic hepatitis B.
 PMID: 19566788       2010       Journal of viral hepatitis
Abstract: Each amino-acid substitution appeared alone and included rtA194T, rtV214A, rtQ215S, rtI233V and rtN236T.


  Hepatitis B viral surface mutations in patients with adefovir resistant chronic hepatitis B with A181T/V polymerase mutations.
 PMID: 20119580       2010       Journal of Korean medical science
Discussion: Drug resistant mutations to ADV have been reported mainly in the HBV polymerase domain D rtN236T or the domain B rtA181V/T.
Discussion: Whereas a domain D rtN236T mutation does not overlap with the envelope gene, a mutation at rtA181T can result in a stop mutation in the envelope region of the S gene (sW172stop).


  Mechanistic characterization and molecular modeling of hepatitis B virus polymerase resistance to entecavir.
 PMID: 20169198       2010       PloS one
Method: Additional HBV-RT homology models were constructed with the LVD (M204V+L1
Discussion: In contrast, resistance to adefovir leading to virologic breakthrough can arise from either A181 V or T substitutions, or N236T.
Discussion: Modeling studies suggest that the N236T change may indirectly affect binding of the terminal gamma-phosphate of adefovir-diphosphate and changes at A181 of the alpha helix adjacent to the YMDD active site loop likely affect the position of the YMDD loop itself or the nucleotide in the +1 position through interactions of A181V or T with the M204 S-methyl moiety of the YMDD loop.


  Establishment of a new quantitative detection approach to adefovir-resistant HBV and its clinical application.
 PMID: 20222172       2010       World journal of gastroenterology
Abstract: Among the 32 clinical patients, single rtA181 and rtN236T mutation and double rtA181T and rtN236T mutations were detected in 20 and 8, respectively, while ADV-resistant mutations in 6 (including, rtA181V/T mutation alone in 5 patients) and no associated mutations in 26.
Abstract: METHODS: Based on the characteristics of rtA181V/T and rtN236T mutations, a new approach based on real-time fluorescent quantitative polymerase chain reaction (RT-PCR) was established for the detection of ADV-resistant HBV quasispecies, to


  Hepatitis B virus drug resistance in HIV-1-infected patients taking lamivudine-containing antiretroviral therapy.
 PMID: 20377434       2010       AIDS patient care and STDs
Abstract: All 19 patients with HBV-DR had lamivudine resistance with the mutations as follows: M204V/I (95%), L180M/A181T (95%), L80V/I (47%), V173L (32%), and N236T (21%).



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