Abstract: Surprisingly, adefovir therapy failed, although none of the virus isolates displayed mutations known to be associated with adefovir resistance (A181V, N236T).
Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase.
Abstract: In vitro testing of a laboratory strain encoding the rtN236T mutation and testing of patient-derived virus confirmed that the rtN236T substitution caused a marked reduction in susceptibility to adefovir.
HBV mutation literature information.
PMID: 
2004
AIDS (London, England)
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