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 HBV mutation literature information.


  Detection of the rtA181V/T and rtN236T mutations associated with resistance to adefovir dipivoxil using a ligase detection reaction assay.
 PMID: 19651117       2009       Clinica chimica acta; international journal of clinical chemistry
Abstract: CONCLUSIONS: The PCR-LDR assay can sensitively and specifically detect the rtA181V/T and rtN236T mutations, and may be used for monitoring ADV resistance in patients infected with HBV.
Abstract: We developed a sensitive and specific method for detecting the rtA181V/T and rtN236T mutations associated with ADV resistance in chronic hepatitis B patients, based on a ligase detection reaction (LDR).


  Prevalence of hepatitis B virus DNA polymerase mutations in treatment-naive patients with chronic hepatitis B.
 PMID: 19785624       2009       Alimentary pharmacology & therapeutics
Abstract: CONCLUSIONS: No rtM204V/I or rtN236T mutations were observed in our study.


  [Dissection of mechanism for the adefovir dipivoxil resistance in chronic hepatitis B patients].
 PMID: 19874686       2009       Zhonghua gan zang bing za zhi
Abstract: The classic mutation sites such as rtN236T and rtA181V/T were not found.


  Evolution of hepatitis B virus mutation during entecavir rescue therapy in patients with antiviral resistance to lamivudine and adefovir.
 PMID: 19918102       2009       Antiviral therapy
Abstract: RESULTS: During 3TC and ADV therapy, 11 patients had rtM204V/I mutations, 2 had rtA181V/T or rtN236T, 7 had both and 2 had no 3TC- or ADV-related mutations.
Abstract: Relative abundances of rtM204V/I mutations in total viral populations gradually increased under ETV rescue, whereas those with rtA181V/T and rtN236T mutations decreased.


  New approaches in the management of chronic hepatitis B: role of tenofovir.
 PMID: 21694884       2009       Infection and drug resistance
Method: In vitro studies, however, show that both rtN236T and rtA181V/T HBV mutants remain sensitive to TDF, and are only associated with small decreases in susceptibility.


  Tenofovir monotherapy is effective in hepatitis B patients with antiviral treatment failure to adefovir in the absence of adefovir-resistant mutations.
 PMID: 18199519       2008       Journal of hepatology
Abstract: Among patients with suboptimal virologic response, rtA181T, rtI233V, and rtN236T were present on clonal analysis in 3 patients.
Abstract: RESULTS: ADV-resistant mutations, rtA181V and rtN236T, were detected on direct sequencing in 3 of 8 patients who had virologic breakthrough.


  Evaluation of initial virological response to adefovir and development of adefovir-resistant mutations in patients with chronic hepatitis B.
 PMID: 18221300       2008       Journal of viral hepatitis
Abstract: Five (12%) patients developed ADV-resistant mutations: rtN236T in four cases and one case with an rtV207L change, which has not been previously reported.


  [Kinetics of HBV mutants conferring adefovir resistance (rtn236t) and a method to detect them rapidly].
 PMID: 18226341       2008       Zhonghua gan zang bing za zhi
Abstract: A novel PCR-RFLP assay based on restriction enzyme HpaI or DraI for on the detection of rtN236T mutant was established, which detected 10% minor strains with 100% specificity.
Abstract: CONCLUSIONS: A rapid and easy method was established to detect rtN236T mutants.
Abstract: In one patient after stopping the adefovir therapy, 3 months later a wild type virus re-took again the mutant one (rtN236T); in one patient who developed a rt236T mutant after 132 weeks of adefovir treatment, a novel mutant (rtN236V) appeared and then became the dominant one while adefovir treatment continued.

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