literature

HBV mutation literature information.

Hepatitis B virus wild-type and rtN236T populations show similar early HBV DNA decline in adefovir refractory patients on a tenofovir-based regimen.

PMID: 23967738 2013 Zhonghua gan zang bing za zhi

Abstract: METHODS: Sixty-five adult CHB patients (age range: 20-60 years) who were unresponsive to ADV therapy (HBeAg-positive; HBV DNA >or= 10(5) copies/ml), LAM-naive, and tested positive for the rtN236T HBV mutation were enrolled in the study and randomly divided into two treatment groups: Group A (n = 33), who were administered ADV (10 mg/day, orally) plus peg-IFN (180 microg/week, subcutaneous injection) for 48 weeks; and Group B (n = 32 patients), who received the ADV plus LAM (100 mg/day, orally) for 48 weeks followed by continued LAM treatment for an additional 24 weeks.

Abstract: OBJECTIVE: To compare the efficacy and safety of the common antivirals, including adefovir dipivoxil (ADV), pegylated-interferon alpha-2a (peg-IFN) and lamivudine (LAM), used as combination therapies to treat

[Detection of resistance mutations in chronic hepatitis B patients receiving antiviral therapy for over one year].

PMID: 23971924 2013 Mikrobiyoloji bulteni

Abstract: In one sample which had multiple mutations associated with LVD resistance single mutations (S202G, N236T) associated with entecavir resistance and in two other such samples mutations associated with adefovir resistance were detected by SEQ.

Profile of hepatitis B virus resistance mutations against nucleoside/nucleotide analogue treatment in Chinese patients with chronic hepatitis B.

PMID: 24160943 2013 Virology journal

Introduction: According to previously studies, the patterns of genotypic resistance in the HBV polymerase can be categorized into five specific evolutionary pathways, including L-nucleoside pathway (rtM204I [or V or I/V]), the acyclic phosphonate pathway (rtN236T), the shared pathway (rtA181T [or V or T/V]) of both L-nucleoside and acyclic phosphonate, ETV resistance pathway (rtL180M+rtM204V with one of either rtT184, S202 or M250 residue changes) and multidrug resistance pathways (rtA181T+

Substitution rtq267h of hepatitis B virus increases the weight of replication and Lamivudine resistance.

PMID: 24348637 2013 Hepatitis monthly

Introduction: Substitution rtA181V/T and/or rtN236T can reduce the anti-HBV effect of ADV, rtN238R, rtT240Y and rtN248H of HBV were newly reported to decrease susceptibility to ADV (8).

Hepatitis B virus genotype C encoding resistance mutations that emerge during adefovir dipivoxil therapy: in vitro replication phenotype.

PMID: 26201776 2013 Hepatology international

Abstract: CONCLUSIONS: The identification of secretion-defective HBV in the setting of ADV therapy for HBV genotype C, and to a lesser extent HBV genotype B, has major implications for the diagnosis and treatment of HBV in the Asia-Pacific region, as it is likely that quantitative HBsAg and viral load testing of serum from patients infected with HBV encoding rtA181T and rtN236T substitutions may not accurately reflect the level of replication within hepatocytes.

Five years of treatment with adefovir dipivoxil in Chinese patients with HBeAg-positive chronic hepatitis B.

PMID: 22097972 2012 Liver international

Abstract: Urgent switch or add-on therapy with a nucleoside analogue is necessary if ADV resistant mutations are detected, particularly rtN236T.

Abstract: Virological breakthrough associated with ADV resistant mutations (rtN236T and rtA181V) occurred in 14.6% of subjects.

Risk factors of gene-resistant mutations in different nucleosides.

PMID: 22260834 2012 Hepato-gastroenterology

Abstract: In LAM group, rtL180M combined with rtM204V mutations accounted for 32.7% and in ADV group, rtN236T mutation accounted for 12.3%.

An improved reverse dot hybridization for simple and rapid detection of adefovir dipivoxil-resistant hepatitis B virus.

PMID: 22290465 2012 Genetics and molecular research

Abstract: Thisreverse dot hybridization assay proved to be simple and rapid for detection ofrtA181V/T and rtN236T mutations associated with resistance to adefovirdipivoxil.

Abstract: Wedeveloped an improved reverse dot hybridization test for simple and rapiddetection of the rtA181V/T and rtN236T mutations associated with adefovirdipivoxil resistance in chronic hepatitis B patients.

High-resolution melting and real-time PCR for quantification and detection of drug-resistant HBV mutants in a single amplicon.

PMID: 22301217 2012 Antiviral therapy

Abstract: HRM analysis produced distinct melting temperatures that clearly distinguished the mutants, rtM204V/I (LMV), rtA181V and rtN236T (ADV), and rtT184G and rtM250V (ETV), from their respective wild types.

Decreased infectivity of nucleoside analogs-resistant hepatitis B virus mutants.

PMID: 22314422 2012 Journal of hepatology

Abstract: METHODS: HBV-resistant mutants (rtL180M+M204V, rtV173L+L180M+M204V, rtM204I, rtL180M+M204I, rtN236T, rtA181V, rtA181V+rtN236T, rtA181T+N236T, and rt

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