literature

HBV mutation literature information.

Occult HBV infection in Chinese blood donors: role of N-glycosylation mutations and amino acid substitutions in S protein transmembrane domains.

PMID: 31516090 2019 Emerging microbes & infections

Result: Introduction of the N146D/S/Y mutations in plasmid M88 and P38.II by SDM did not significantly alter the EC and IC HBsAg production pattern, although a slight reduction in HBsAg secretion was observed for P38.II mutants, as reflected by the decreased HBsAg EC/IC ratio compared to that of wt HBsAg (5-8 versus 17) (Figure 3).

Result: Mutants N146D/S/Y showed an expected non-glycosylated profile.

Result: Particularly, mutations removing the N146 glycosylation site (N146D/S/Y) were found in 4.4% (2/45) and 6% (3/50) of OBI genotype B (OBIB) and genotype C (OBIC) sequences, respectively.

Functional analysis of 'a' determinant mutations associated with occult HBV in HIV-positive South Africans.

PMID: 27031988 2016 The Journal of general virology

Abstract: Of the seven mutations analysed, four (S132P, C138Y, N146D and C147Y) resulted in decreased HBsAg expression in one viral background but not in the second viral background.

Abstract: One mutation (N146D) led to a decrease in HBsAg detected as compared to HA-tag, indicating that this mutation compromises the ability of the ELISA to detect HBsAg.

A novel nucleotide insertion in S gene of hepatitis B virus in a chronic carrier.

PMID: 20492719 2010 Virology journal

Abstract: S114T, C121Y, T126S/A, Q129K, G130R, T131N, M133T, G145R, N146D substitution and premature stop codon were also found in those clones.

Result: N146D substitution(AAC GAC) occurred in clone5-clon6 at aa146, leading to loss of N-linked glycosylation site at this position.

Hepatitis B surface antigen variants in vaccinees, blood donors and an interferon-treated patient.

PMID: 11264736 2001 Journal of viral hepatitis

Abstract: Three of seven anti-HBc positive Chinese blood donors had a T131I substitution, whilst the interferon-treated patient had a treble amino acid substitution (P142S, G145R and N146D).

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