literature

HBV mutation literature information.

Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression.

PMID: 29713126 2018 World journal of gastroenterology

4Method: Of six positions' mutation in the A-B interdomain, three RT mutations, rtD134E/N, rt Method: Of note, the following four putative or pretreatment mutations found in treatment naive patients, rtD134E/N, rtN139D/E/H/K/Q, rtF221Y, and rtI224V, are also reported as associated with progression of severe liver diseases, such as HCC and cirrhosis (described below).

Occult HBV Infection May Be Transmitted through Close Contact and Manifest as an Overt Infection.

PMID: 26457811 2015 PloS one

Result: Amino acid substitutions in mother include T16I, R41S, V44A,N53S, H55R, W58R, N76D, S81T, V103I, G107E, N121I, I122L, N123D, Q125K, H126Y, N134D, N139H, N139Q, Y158H, I163V, F178L, S185N, V207M

Characterization of antiviral resistance mutations among the Eastern Indian Hepatitis B virus infected population.

PMID: 23409946 2013 Virology journal

Table: N139E/Q

Table: N139Q

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