Introduction: Recently, HBVrt domain mutations which have been reported in the literature as supposed drug resistant mutations but are not verified experimentally were classified as putative NA resistant (NAr) mutations (such as
S53N,
T54N,
L82M,
V84M,
S85A,
I91L,
Y126C,
T128I,
T128N,
N139D,
W153Q,
F166L).