In silico functional and structural characterization of hepatitis B virus PreS/S-gene in Iranian patients infected with chronic hepatitis B virus genotype D.
Introduction: This study attempted to identify mutations (K122R, N131T, F134Y, P142L, and T126N) in S gene, N-glycosylation sites (4, 112, 166, and 309), compare Ahvaz samples with isolates from other regions of the world using the phylogenetic tree, and investigate the tertiary structures of isolates.
Result: The results of our amino acid sequences of the preS/S gene compared to consensus genes showed several mutations at position L109R, T113S, K122R, T126N, N131T, F134Y,
Impact of immune escape mutations and N-linked glycosylation on the secretion of hepatitis B virus virions and subviral particles: Role of the small envelope protein.
Discussion: We further demonstrated that ability of the M133T mutation to rescue virion secretion of the I110M, G119E, and G145R mutants was abrogated by an additional N131Q or N131T mutation indicating that glycosylation at N131, rather than M133T mutation itself, restored virion secretion.
HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy.
Result: However, out of these 20 S-substitutions, 10 (sT114S, sT126I, sP127T, sN131T, sN143S, sY/S161F, sA194V, sI195M, sW196L and sR210N) remained significant after application of Benjamini-Hochberg correction (Table 2).
Naturally occurring hepatitis B virus B-cell and T-cell epitope mutants in hepatitis B vaccinated children.
8Discussion: We did not find the most important and best-documented G145R mutation, but we found a G145A mutation and other substitutions (T126I, N131T, and T143S) within the ""a"" determinant."
Abstract: Several immune-epitope mutants, such as S45T/A, N131T, I194V, and S207N in S, were detected in all isolates.
Conclusion: Several immune-epitope mutants, such as S45T/A, N131T, I194V, and S207N in S, were detected in all isolates and needed to explore
Impairment of hepatitis B virus virion secretion by single-amino-acid substitutions in the small envelope protein and rescue by a novel glycosylation site.
Abstract: Destroying this site by N131Q/T mutation or preventing glycosylation by tunicamycin treatment of transfected cells abrogated the effect of the M133T mutation.
"De novo acute hepatitis B infection in a previously vaccinated liver transplant recipient due to a strain of HBV with a Met 133 Thr mutation in the ""a"" determinant."
1Abstract: Subsequent analysis of the predominant HBV strain revealed mutations in the ""a"" determinant: Met 133 Thr (codon change ATG to ACG) and Asn 131 Thr."
HBV mutation literature information.
PMID: 
2020
Heliyon
Browser Board
Co-occurred Entities
Filtrator
ViMRT