Identification of hepatitis B virus rtS117F substitution as a compensatory mutation for rtM204I during lamivudine therapy.
PMID: 22001270
2012
The Journal of antimicrobial chemotherapy
Abstract: Emergence of the rtS117F mutation was associated with an increase in hepatitis activity, whereas prior existence of the rtN124D mutation was associated with decompensated liver function upon development of the rtM204I mutation.
Abstract: Prior existence of the rtN124D substitution was associated with liver decompensation upon development of the rtM204I mutation.
Abstract: RESULTS: Of the 49 patients carrying the rtM204I mutation, 5 subsequently developed an rt
[HBV gene variants and polymerse gene mutations in children with chronic hepatitis B in the course of the antiviral therapy].
Abstract: YIDD mutation appeared to be the single one in the viral polymerase gene, while YVDD mutations in four patients were accompanied by other changes at amino acid sequence of the HBV polymerase: rtL180M, rtN124D and rtL164M.
HBV mutation literature information.
PMID: 
2012
The Journal of antimicrobial chemotherapy
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