Abstract: Among five patients after 12 months of lamivudine treatment, M552I mutations in two patients with HBV DNA rebounding and D553G mutation in one non-responder were detected except two patients with negative HBV DNA consecutively.
[Dynamic variations of hepatitis B virus polymerase gene in lamivudine-treated hepatitis B patients].
Abstract: RESULTS: Among five patients after 12 months lamivudine treatment, M552I mutations in two patients with HBV DNA rebounding and D553G mutation in one non-responder were detected except in two patients with negative HBV DNA.
Efficacy of alpha interferon therapy for lamivudine resistance in chronic hepatitis B.
PMID: 15311721
2004
International journal of clinical practice
Abstract: Genotypic analysis showed M552V, M552I and L528M mutations.
Detection of YMDD motif mutants by oligonucleotide chips in lamivudine-untreated patients with chronic hepatitis B virus infection.
PMID: 15308845
2004
Journal of Korean medical science
Abstract: M552I mutants were detected by the oligonucleotide chips in 7.5% (3/40) of chronic HBV infected patients (2 chronic hepatitis and 1 cirrhosis).
Abstract: Serum samples were tested by the oligonucleotide chips designed for detection of wild-type YMDD motif, M552V and M552I.
Introduction: The most common mutants have a change at codon 552 from M to V (M552V) or from M to I (M552I).
Fibrosing cholestatic hepatitis secondary to precore/core promoter hepatitis B variant with lamivudine resistance: successful retransplantation with combination adefovir dipivoxil and hepatitis B immunoglobulin.
Abstract: Comparison of the HBV polymerase gene in the 2 serum samples revealed a single mutation with methionine-to-isoleucine substitution at codon 552 (M552I) in both patients.
Detection of hepatitis B virus variants resistant to lamivudine and famciclovir among randomly selected chronic carriers from Spain.
PMID: 14987532
2004
Enfermedades infecciosas y microbiologia clinica
Abstract: Wild-type strains together with either the rtM204I (M552I) or rtV207I (V555I) point mutation were found in two of these cases, and the rtV207I mutation alone was detected in the third.
Evolution of hepatitis B virus sequence from a liver transplant recipient with rapid breakthrough despite hepatitis B immune globulin prophylaxis and lamivudine therapy.
1Abstract: These mutations caused L426I/L526M/M550I triple mutation (equivalent to L428I/L528M/M552I in previous reports) in the polymerase, and D144E mutation in the ""a"" determinant of HBsAg."
Genotypic and phenotypic resistance: longitudinal and sequential analysis of hepatitis B virus polymerase mutations in patients with lamivudine resistance after liver transplantation.
PMID: 12526951
2003
The American journal of gastroenterology
Abstract: METHODS: Sequential serum samples from 10 consecutive patients with lamivudine resistance after liver transplantation were analyzed for viral genotype, precore mutants, and viral polymerase gene mutants (L528M, M552V, M552I) using restriction fragment length polymorphism.
Abstract: The M552I pure viral population was found mainly in these patients, and all retained stable graft function (median follow-up 33 months).
[Natural YMDD motif mutations of HBV polymerase in the chronic hepatitis B virus infected patients].
Abstract: To detect YMDD mutants, YVDD (M552V), and YIDD (M552I), we used direct sequencing and the restriction fragment length polymorphism (RFLP) method.
[Detection and identification of emergence of HBV YMDD motif mutation during lamivudine treatment by hybridization to an oligonucleotide array].
PMID: 15340547
2003
Zhonghua shi yan he lin chuang bing du xue za zhi
Abstract: By direct sequencing of the PCR products, 11 cases were found to have YVDD with adenine741 changed into cytidine resulted in methionine552 changed into valine in which 6 cases with adenine669 changed into cytidine and leucine changed into methionine, 10 cases had YIDD motif mutation with guanosine743 altered thymidine methionine552 changed into isoleucine, including 3 cases with thymidine281 changed into cytidine and leucine565 altered proline.
HBV mutation literature information.
PMID: 
2008
Microbiological research
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