Abstract: A number of significant drug resistant mutations were found in five patients including S202I, N236T, M250L, L180M/V, M204I, A181T, T184G, M250V, and V173L.
Result: Patient 247131 was found to have mutations L180M, M204I, T184G, and M250V, which were associated with resistance to lamivudine, entecavir, emitricitabine, famciclovir, and telbivudine.
Table: M250V
Substitution rtq267h of hepatitis B virus increases the weight of replication and Lamivudine resistance.
Introduction: Interestingly, resistance to ETV includes LAM resistance mutations, rtM250V+-rtI169T+rtM204V+rtL180M and rtT184G+rtS202I+rtM204V+rtL180M.
Discussion: In another large-scale study, three out of 255 (1.2%) treatment-naive patients had the rtM250L/V mutation typical of ETV resistance.
Drug-related mutational patterns in hepatitis B virus (HBV) reverse transcriptase proteins from Iranian treatment-naive chronic HBV patients.
Result: rtV173L, rtL180M, rtA181V/T, rtT184G, rtS202I, rtM204V/I, rtN236T and rtM250V were first studied and then, others residues with changes present in at least two patients were further considered.
Characterization of antiviral resistance mutations among the Eastern Indian Hepatitis B virus infected population.
Abstract: Clonal sequencing was conducted on 192 clones isolated from three patients and showed rtA181T, rtM250V and rtS202G mutations at an overall frequency of 1.54%, 1.39%, and 1.67% respectively.
Clonal analysis of the quasispecies of antiviral-resistant HBV genomes in patients with entecavir resistance during rescue treatment and successful treatment of entecavir resistance with tenofovir.
HBV mutation literature information.
PMID: 
2014
PloS one
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