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 HBV mutation literature information.


  Mechanistic characterization and molecular modeling of hepatitis B virus polymerase resistance to entecavir.
 PMID: 20169198       2010       PloS one
Result: Alternatively, in the model of M250V, the valine side chain pack
Result: In contrast, ETVr due to substitutions of M250V or M250L in LVDr HBV was found to be manifested primarily during RNA-directed minus strand DNA synthesis, as the EC50 for the first (minus) strand was increased relative to that for the second (plus) strand.
Result: M250 substitutions that were smaller than methionine and replicated well, M250A/G/S/T/C/D/E/Q/N/V/L/I, were all resistant.


  Evolution of hepatitis B virus polymerase mutations in a patient with HBeAg-positive chronic hepatitis B virus treated with sequential monotherapy and add-on nucleoside/nucleotide analogues.
 PMID: 19302908       2009       Clinical therapeutics
Abstract: A total of 20.6% (7/34) of the clones harbored the rtK212T + rtM250L mutation, and rtA181V was found in 2.9% (1/34) of the clones.


  Primary resistance, multidrug resistance, and cross-resistance pathways in HBV as a consequence of treatment failure.
 PMID: 19669299       2008       Hepatology international
Abstract: Finally, in highly drug-experienced patients, clusters of mutations such as rtA181T/I233V/N236T/M250L, all on the one dominant HBV genome, are being detected which are associated with multi-drug resistance.



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