literature

HBV mutation literature information.

Genotypic resistance profile of hepatitis B virus (HBV) in a large cohort of nucleos(t)ide analogue-experienced Chinese patients with chronic HBV infection.

PMID: 21392168 2011 Journal of viral hepatitis

Method: The rtT184A/C/F/G/I/L/M/S, rtS202C/G/I and rtM250I/L/V were defined as the signature ETV-resistant mutations (ETV-R) if concomitant with rtM204I/V.

Table: M250I

[Detection of HBV resistant mutations related to lamivudine, adefovir and entecavir by reverse hybridization technique].

PMID: 20587309 2010 Zhonghua gan zang bing za zhi

Abstract: To detect non-synonymous amino acid substitutions associated with lamivudine, adefovir and entecavir, 26 specific oligonucleotide probes covering ten different codon positions, I169T, V173L/G, L180M, A181T/V, T184G, S202I/G, M204V/I, Q215S, N236T and M250V/I/L were synthesized and immobilized on nylon membranes charged positively.

Mechanistic characterization and molecular modeling of hepatitis B virus polymerase resistance to entecavir.

PMID: 20169198 2010 PloS one

Result: M250 substitutions that were smaller than methionine and replicated well, M250A/G/S/T/C/D/E/Q/N/V/L/I, were all resistant.

Result: Several different ETVr substitutions have been observed in ETV-treated patients, including T184A/C/F/G/I/L/M/S, S202C/G/I, and M250 I/L/V.

Discussion: Indeed the variety of ETVr substitutions found in patients includes T184A, C, F, G, I, L, M or S, S202C, G or I, and M250 I, L or V.

Prevalence of hepatitis B virus DNA polymerase mutations in treatment-naive patients with chronic hepatitis B.

PMID: 19785624 2009 Alimentary pharmacology & therapeutics

Abstract: Some (16.7%) had mutations of unknown clinical significance (rtV207M/L/I) and only 4 patients had rtA181A/S, rtA194S or M250I.

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