literature

HBV mutation literature information.

Comparison of Detection Rate and Mutational Pattern of Drug-Resistant Mutations Between a Large Cohort of Genotype B and Genotype C Hepatitis B Virus-Infected Patients in North China.

PMID: 27792585 2017 Microbial drug resistance (Larchmont, N.Y.)

Abstract: For entecavir-resistant mutations, HBV/C-infected patients had a higher detection rate of rtM204 V/I+T184 substitution or S202G/C (3.66% vs. 2.16%, p < 0.01) and a lower detection rate of rtM204 V/I+M250 V/I/L substitution (0.67% vs. 1.46%, p < 0.01).

Pre-existing mutations related to tenofovir in chronic hepatitis B patients with long-term nucleos(t)ide analogue drugs treatment by ultra-deep pyrosequencing.

PMID: 27602500 2016 Oncotarget

Discussion: In one article, the most commonly detected mutations were M204V/I(9/14) and M250V/I(11/14); other documented mutations include A181T/V(7/14) and N236T(3/14).

Dynamics of Genotypic Mutations of the Hepatitis B Virus Associated With Long-Term Entecavir Treatment Determined With Ultradeep Pyrosequencing: A Retrospective Observational Study.

PMID: 26825915 2016 Medicine

Discussion: One study reported that the most commonly detected mutations were M204 V/I, M250 V/I, A181T/V, and N236T.

Substitution at rt269 in Hepatitis B Virus Polymerase Is a Compensatory Mutation Associated with Multi-Drug Resistance.

PMID: 26322642 2015 PloS one

Introduction: They include rtI169T, rtL180M, rtS184S/A/I/L/G/C/M, M204I/V, rtS202G/I, and rtM250I/V.

Analysis of HBV genotype, drug resistant mutations, and pre-core/basal core promoter mutations in Korean patients with acute hepatitis B.

PMID: 25712861 2015 Journal of medical virology

Abstract: No patient showed mutations that conferred resistance against lamivudine (L180M, M204V/I), adefovir (A181T, N236S), or entecavir (I169M, A184T/V, S202I/G, M250V/I/L).

Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma.

PMID: 24788140 2014 PloS one

Result: It is worth noting that we did not observe any of the common NA-related resistance mutations including rtM204V/I, rtS202C/G/I, rtL180M, rtA181T/V, rtT184A/I/L/G/C/M, rtA194T, rtI169T, rtV173L, rtL80I, rtN236T, and

PMID: 24348637 2013 Hepatitis monthly

Introduction: A combination of mutations in the B, C, or D domain, such as rtI169T, rtM250I/V, and a background of rtM204V/I confer resistance to ETV.

Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients.

PMID: 22882650 2012 Liver international

Method: The primary drug resistant mutations were defined as nucleotide mutation(s) caused an amino acid substitution that resulted in reduced susceptibility to an antiviral drup, such as rtL180M, rt204I/V for lamivudine, rtL180M+rtM204I/V+rtS202C or rtM250I/V for entecavir; rtA181T/V, rtN236T for adefovir dipivoxil; rtM204I for telbivudine.

Ultra-deep pyrosequencing detects conserved genomic sites and quantifies linkage of drug-resistant amino acid changes in the hepatitis B virus genome.

PMID: 22666402 2012 PloS one

Method: NA-resistance-related aa substitutions outside the B and C domains, such as rtI233V, rtN236T and rtM250I/V, were not considered relevant for the aims of the study, since they had not been detected du

Discussion: In addition, due to the 250-bp-length limitation of the standard GS-FLX chemistry, the relevant NA-resistant substitutions, rtI233V and rtN236T linked to ADV treatment failure, and rtM250I/V linked to ETV failure, located outside the B and C HBV RT functional domains, were excluded from the fragment analyzed.

Dynamics of hepatitis B virus quasispecies in association with nucleos(t)ide analogue treatment determined by ultra-deep sequencing.

PMID: 22523569 2012 PloS one

Table: M250V/I

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