Abstract: The data showed different compensatory changes followed by the rtM204I/V.
Discussion: Although the lamivudine-induced rtM204I/V mutation might occur in any genotype, the compensatory mutations are not consistent in different genotypes.
Discussion: By the naive Bayes classification algorithm and the complete induction method based on the comparative sequence analysis, this study presents more detailed subsequent mutations followed with the lamivudine-induced rtM204I/V mutation.
Discussion: For instance, the previous studies reported a high incidence rate of rtL180M followed by YMDD variance, here we deeply figure out that the
Pre-existing mutations related to tenofovir in chronic hepatitis B patients with long-term nucleos(t)ide analogue drugs treatment by ultra-deep pyrosequencing.
Result: At baseline, patient 2 harbored the rtA181T (4.7%), rtN236T (5.7%), rtL180M (12.5%), rtS202G (3.2%), and rtM204I/V (7%) substitutions, and other resistance mutations were present at low levels (<1%).
Result: At baseline, this patient carried with rtL180M (2.4%), rtM204I/V (3.4%), rtS202G (3.3%), rtA181V/T (4.7%), and
Monitoring of genotypic resistance profile in chronic hepatitis B patients receiving nucleos(t)ide analogues in Huzhou, China.
PMID: 27694733
2016
Journal of infection in developing countries
Abstract: Among patients who harbored rtM204 combination mutations, rtM204I and rtM204V were significantly associated with rtL80I/V and rtL180M, respectively.
Serologic and genotypic characterization of hepatitis B virus in HIV-1 infected patients from South West and Littoral Regions of Cameroon.
Discussion: The rtL180M + rtT184S + rtM204V triple mutation found in one patient suggests resistance to ente
Discussion: The mutation rtL180M found together with the rtM204V mutation in these patients is associated with resistance to telbivudine and also with enhanced replication.
Discussion: The replacement of methionine in the YMDD catalytic site motif by valine (rtM204V) in the seven patients is associated with resistance to lamivudine and other L-nucleoside analogues.
Comparative evaluation of long-term monotherapies & combination therapies in patients with chronic hepatitis B: A pilot study.
PMID: 28139541
2016
The Indian journal of medical research
Abstract: Mutations: rtM204V (39.3%), M204V+L180M (10.7%) while rtA181V (8.1%) and rtN236T (8.3%) were observed with LAM and ADV regimen, respectively.
Result: Mutation in the YMDD, M204V (methionine to valine) in 39.3 per cent and along with L180M (leucine to methionine) in 10.7 per cent was detected in the conserved regions C and B of reverse transcriptase (rt) domain of HBV polymerase, respectively, after 24 months of LAM therapy.
Discussion: In addition, t
Betaine Inhibits Hepatitis B Virus with an Advantage of Decreasing Resistance to Lamivudine and Interferon alpha.
PMID: 27144395
2016
Journal of agricultural and food chemistry
Abstract: BET suppressed HBV DNA rebound produced by the resistance of HBV to lamivudine and decreased the resistance mutation (rtM204V/I) of HBV DNA.
De novo entecavir+adefovir dipivoxil+lamivudine triple-resistance mutations resulting from sequential therapy with adefovir dipivoxil, and lamivudine.
PMID: 27079793
2016
Annals of clinical microbiology and antimicrobials
Abstract: Specifically, we found one rtM204I+rtL180 M+rtM250 V+rtA181 V clone among 23 clones from patient 1 (4.35 %), one rtM204 V+vrtL180 M +rtM250 V+rtA181 V clone among 24 clones from patient 2 (4.17 %), and 2 clones harboring rtM204 V+rtL180 M+rtM250 V+rt
Higher detection rates of amino acid substitutions in HBV reverse transcriptase/surface protein overlapping sequence is correlated with lower serum HBV DNA and HBsAg levels in HBeAg-positive chronic hepatitis B patients with subgenotype B2.
PMID: 27006281
2016
Infection, genetics and evolution
Abstract: In addition, two patients harboring drug resistance mutations rtL80V+rtM204I and rtL180M+rtM204V were found.
Evolution of entecavir-resistant hepatitis B virus during entecavir and adefovir dipivoxil combination therapy.
PMID: 26889227
2016
Experimental and therapeutic medicine
Abstract: Clonal analysis further revealed that the rtS202G or rtT184F was in all cases co-localized with rtL180M and rtM204V in any single virus isolate clone.
Abstract: In patient A, the rtL180M, rtS202G and rtM204V mutant variants were detected using pyrosequencing prior to virological breakthrough.
HBV mutation literature information.
PMID: 
2016
Journal of virological methods
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