ViMRT
}  
 
Home   
< Docs   

 HBV mutation literature information.


  Successful rescue therapy with tenofovir in a patient with hepatic decompensation and adefovir resistant HBV mutant.
 PMID: 16405720       2006       Comparative hepatology
Conclusion: Sequencing of the HBV polymerase revealed two common lamivudine resistant mutations - rtL180M and rtM204V.
Conclusion: Two adefovir resistant mutations, rtA181T and rtN236T, were detected, whereas previous lamivudine resistant mutations, rtL180M and rtM204V, were absent.
Discussion: reported recently decreased in vitro susceptibility to both tenofovir and adefovir of two HBV resistant mutants (N236T adefovir and


  Inhibition of hepatitis B virus (HBV) replication by pyrimidines bearing an acyclic moiety: effect on wild-type and mutant HBV.
 PMID: 16539393       2006       Journal of medicinal chemistry
Abstract: These compounds were also found to retain sensitivity against lamivudine-resistant HBV containing a single mutation (M204I) and double mutations (L180M/M204V).


  Characteristics of drug resistant HBV in an international collaborative study of HIV-HBV-infected individuals on extended lamivudine therapy.
 PMID: 16549970       2006       AIDS (London, England)
Abstract: The triple polymerase mutant (rtL173V, rtL180M, rtM204V), which behaves as a vaccine escape mutant in vitro, occurred in 17% of viraemic patients.


  Switching to adefovir monotherapy after emergence of lamivudine-resistant mutations in patients with liver cirrhosis.
 PMID: 16611191       2006       Journal of viral hepatitis
Abstract: In conclusion, switching to ADV monotherapy after emergence of LAM-resistant rtM204 I/V is effective and safe in cirrhotic patients, even in those with hepatic decompensation.
Abstract: Switching to adefovir (ADV) monotherapy is effective in patients with lamivudine (LAM)-resistant hepatitis B virus (HBV) mutations (rtM204 I/V).
Abstract: The clinical, biochemical and virological responses were compared between ADV monotherapy in 18 cirrhotic patients and ADV add-on LAM therapy in 10 comparable cirrhotic patients with LAM-resistant rtM204 I/V.


  Predominance of hepatitis B virus YMDD mutants is prognostic of viral DNA breakthrough.
 PMID: 16618409       2006       Gastroenterology
Abstract: RFMP exploits differences in molecular masses between wild-type and variant bases of rtM204V/I following PCR amplification of HBV DNA with a lower limit of detection being 100 copies/mL.


  Antiviral drug resistance: clinical consequences and molecular aspects.
 PMID: 16673294       2006       Seminars in liver disease
Abstract: The rtM204I/V is selected by lamivudine and L-nucleosides.


  Changes in viral loads of lamivudine-resistant mutants and evolution of HBV sequences during adefovir dipivoxil therapy.
 PMID: 16789011       2006       Journal of medical virology
Abstract: Changes in rtM204I and rtL180M viral loads were greater than that of the rtM204V, albeit statistically insignificant.
Abstract: We determined early viral changes (12 weeks) in YMDD mutants (rtM204I [YIDD sequence], rtM204V [YVDD]) and rtL180M in all 39 patients as well as amino acid changes in the polymerase reverse transcriptase (rt) region and


  Mutations in surface and polymerase gene of chronic hepatitis B patients with coexisting HBsAg and anti-HBs.
 PMID: 16830379       2006       World journal of gastroenterology
Abstract: Lamivudine (LMV)-selected mutations were found in three patients who developed anti-HBs, which occurred in amino acid positions (196, 198, 199) of the surface protein and in YMDD motif (M204I/V) of the polymerase protein simultaneously.


  Tenofovir for patients with lamivudine-resistant hepatitis B virus (HBV) infection and high HBV DNA level during adefovir therapy.
 PMID: 16871563       2006       Hepatology (Baltimore, Md.)
Abstract: Lamivudine-associated mutations (rtV173L, rtL180M, rtM204V/I) could be detected in 6 patients at baseline of TDF, but this obviously did not influence the response.


  Detection of YMDD mutation using mutant-specific primers in chronic hepatitis B patients before and after lamivudine treatment.
 PMID: 16981258       2006       World journal of gastroenterology
Abstract: Pair primers specific to rtL180M and rtM204V were selected for YVDD detection.



Browser Board

 Co-occurred Entities




   Filtrator