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 HBV mutation literature information.


  Frequent detection of hepatitis B virus variants associated with lamivudine resistance in treated South African patients infected chronically with different HBV genotypes.
 PMID: 19382250       2009       Journal of medical virology
Abstract: Of the 17 patients, 13 (76.5%) carried YMDD mutations: 7 with rtM204I (2 HBeAg-positive and 5 HBeAg-negative) and 6 with rtM204V (4 HBeAg-positive and 2 HBeAg-negative).


  Alkoxyalkyl esters of 9-(s)-(3-hydroxy-2-phosphonomethoxypropyl) adenine are potent and selective inhibitors of hepatitis B virus (HBV) replication in vitro and in HBV transgenic mice in vivo.
 PMID: 19398648       2009       Antimicrobial agents and chemotherapy
Abstract: HDP-(S)-HPMPA retained full activity against HBV mutants resistant to lamivudine (L180M, M204V), but cross-resistance to a mutant resistant to adefovir (N236T) was detected.


  Lamivudine-to-entecavir switching treatment in type B chronic hepatitis patients without evidence of lamivudine resistance.
 PMID: 19475333       2009       Journal of gastroenterology
Abstract: An entecavir-resistant virus having rtM204V, rtL180M and rtS202G substitutions was detected in this patient.


  Effect of HIV co-infection on mutation patterns of HBV in patients with lamivudine-resistant chronic hepatitis B.
 PMID: 19475624       2009       Journal of medical virology
Abstract: Eighty-nine patients infected with HBV (29 co-infected with HIV) with rtM204V or rtM204I mutations were included.
Abstract: In this latter group, the prevalence of the rtV173L + rtL180M + rtM204V triple mutation was 31% versus a prevalence of 3.4% observed among patients infected with HBV only.
Abstract: Multivariate analysis demonstrated that HIV co-infection (adjusted OR 11.2, 95% CI 2.0-61.0) and HBV genotype A (adjusted OR 7.2, 95% CI 1.5-34.8) were the only independent variables associated with the chance of harb


  Characterization of hepatitis B virus reverse transcriptase sequences in Chinese treatment naive patients.
 PMID: 19486254       2009       Journal of gastroenterology and hepatology
Abstract: The M204V/I mutation was found in 1.8% of the strains, 1.2% had L180M+ M204V/I, 0.6% had A181T/V, and only one had all three mutations.


  Quantitative detection of the M204V hepatitis B virus minor variants by amplification refractory mutation system real-time PCR combined with molecular beacon technology.
 PMID: 19553583       2009       Journal of clinical microbiology
Abstract: In all samples M204V positive by sequencing (12/12), the mutant variant was detected as the predominant population (range, 82.76 to 99.43%).
Abstract: Interestingly, in 5 (38%) of 13 samples negative by sequencing, the M204V variant was detected at a ratio above the biological cutoff (0.05 to 28%).
Abstract: The assay represents an efficient technique for the early detection and quantification of M204V variants before mutant strains emerge to dominate the population.


  Prevalence, viral replication efficiency and antiviral drug susceptibility of rtQ215 polymerase mutations within the hepatitis B virus genome.
 PMID: 19586679       2009       Journal of hepatology
Abstract: Replication-competent HBV constructs containing the naturally occurring rtQ215H, rtQ215P and rtQ215S mutations were generated, and compared to wild-type, LAM- (rtM204I, rtL180M/rtM204V) and ADV-resistant (rtN236T) clones.


  Two cases of development of entecavir resistance during entecavir treatment for nucleoside-naive chronic hepatitis B.
 PMID: 19669367       2009       Hepatology international
Abstract: The ETVr-related substitution (S202G), along with LVD-resistance-related substitutions (L180M and M204V), was detected by sequence analysis at week 124 in both case 1 and case 2.


  Prevalence of hepatitis B virus DNA polymerase mutations in treatment-naive patients with chronic hepatitis B.
 PMID: 19785624       2009       Alimentary pharmacology & therapeutics
Abstract: CONCLUSIONS: No rtM204V/I or rtN236T mutations were observed in our study.


  [Identification of factors associated with YMDD mutation in patients with chronic hepatitis B receiving lamivudine treatment].
 PMID: 19785947       2009       Zhonghua gan zang bing za zhi
Abstract: rtM204V mutation in C gene was always accompanied by rtL180M mutation (100%).
Abstract: The rate of rtL180M/M204V mutation in genotype C group was significantly higher than that in genotype B group (77.8% to 25.0%), the same was true for the rtL180M/ M204I mutation (22.2% to 12.5%).
Abstract: There are four types of mutation: rtL180M/M204V, rtL180M/M204I,



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