Incidence of natural resistance mutations in naive chronic hepatitis B patients: a systematic review and meta-analysis.
PMID: 25318660
2015
Journal of gastroenterology and hepatology
Abstract: Mutation rtM204V/I had the highest incidence of 4.89% (95%CI: 4.13-5.65%), and other primary mutations seldom spontaneously occurred.
Long-term outcomes and dynamics of mutants associated with lamivudine-adefovir rescue therapy in patients with lamivudine-resistant chronic hepatitis B.
Abstract: The baseline mutation profiles, rtM204I (p=0.992), rtM204I/V (p=0.177), and rtL180M (p=0.051), were not correlated with the cumulative virological response, and the baseline HBV DNA level (p=0.032) was the only independent predictive factor for cumulative virological response.
Result: Baseline mutation profiles, rtL180M (p=0.051), rtM204I (p=0.992), and rtM204I/V (p=0.177) were not correlated with cumulative virological response (Table 2).
Result: LAM-resistant (rtL180M
Investigation into drug-resistant mutations of HBV from 845 nucleoside/nucleotide analogue-naive Chinese patients with chronic HBV infection.
Result: compared with wild-type mouse model, viral replication decreases about 10.06-fold in the rtL180M-rtM204V double mutants, but increases about 7.79-fold in the rtL180M-rtM204V-rtV173L triple mutants.
Result: suggesting that rtM204V and rtL180M double mutations in LAM-resistant HBV mutants resulted in the decline of replication ability, but the third compensatory rtV173L mutation significantly increased the HBV replication ab
A case of entecavir resistance which is developed after complete viral suppression during entecavir treatment for nucleoside-naive chronic hepatitis B.
PMID: 25910308
2014
The Turkish journal of gastroenterology
Abstract: The ETVr-related substitution (rtS202P) and lamivudine resistance-related substitutions (rtL180M+rtM204V) were detected by DNA sequencing analysis at week 145.
Biochemical and Structural Properties of Entecavir-Resistant Hepatitis B Virus Polymerase with L180M/M204V Mutations.
Abstract: OBJECTIVE: To investigate the relationship between mutations of rtM204V/I (methionine to valine or isoleucine at position rt204 of reverse transcriptase domain) in the hepatitis B virus (HBV) polymerase gene and the G1896A and G1899A single mutations in the pre-eore (PC) region and the A1762T and G1764A double-mutations in the basal core promoter (BCP) region.
Genetic insights on host and hepatitis B virus in liver diseases.
PMID: 25475418
2014
Mutation research. Reviews in mutation research
Abstract: We have described common mutations in the HBV genome (G1896A, rtM204V, rtM204I) which modulate the pathogenesis and carcinogenesis of the liver.
Occult hepatitis B virus infection among blood donors in Colombia.
Discussion: Lai et al, demonstrated that mutations sL173F, sI195M, and sY200H also related to these mutations rtA181V, rtM204V, and rtV208A, all of them associated to interferon resistance.
Discussion: Moreover, the change of Leucine to Methionine has been described in association with other mutations in the YMDD polymerase domain, in particular with the substitutions rtM204V and rt PMID: 25303802
2014
Antiviral research
Abstract: During ADV therapy, most rtM204V/I mutants were replaced by wild type in all 3 patients without the rtA181V/T mutation and in one patient with the rtA181V/T mutation.
Abstract: In patients with the rtA181V/T mutation (n = 6), the rtA181V/T mutant overtook the rtM204V/I mutant in 3 of 4 patients with ADV resistance.
Abstract: The majority of LMV-resistant mutants harbor the rtM204V/I mutation, while a minor fraction harbor the
Performance of LigAmp assay for sensitive detection of drug-resistant hepatitis B virus minor variants in comparison with standard nucleotide sequencing.
Abstract: Among these subjects, rtM204V and rtM204I (ATT) mutations were identified by standard sequencing in 10 (25%) and 12 (30%) subjects, respectively.
Abstract: CONCLUSIONS: This data shows significantly higher sensitivity of LigAmp for detection of minority rtM204V and rtM204I (ATT) mutations over standard sequencing.
Abstract: LigAmp detected both rtM204V and rtM204I (ATT) mutations in 13 (32.5%) subjects, rtM204I mutation in 12 (30%) subjects and rt
HBV mutation literature information.
PMID: 
2015
Journal of gastroenterology and hepatology
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