literature

HBV mutation literature information.

HIV therapy with unknown HBV status is responsible for higher rate of HBV genome variability in Ethiopia.

PMID: 27354181 2017 Antiviral therapy

Abstract: Despite the finding that rtL180M and rtM204V/I were higher among ART-experienced individuals, the overall prevalence of DRMs (48.0% versus 36.4%) showed no significance difference among antiretroviral therapy (ART) status.

Abstract: Lamivudine selected DRMs, that is, rtL180M (29.3%) and rtM204V/I (29.3%) and rtV173L (15.5%) were more prevalent in HBV-HIV-coinfected individuals but absent in HBV-monoinfected individuals.

Abstract: RESULTS: In 34 out of 161 study subjects (21.1%) HBV drug resistance mutations (DRM

Comparison of Detection Rate and Mutational Pattern of Drug-Resistant Mutations Between a Large Cohort of Genotype B and Genotype C Hepatitis B Virus-Infected Patients in North China.

PMID: 27792585 2017 Microbial drug resistance (Larchmont, N.Y.)

Abstract: For entecavir-resistant mutations, HBV/C-infected patients had a higher detection rate of rtM204 V/I+T184 substitution or S202G/C (3.66% vs. 2.16%, p < 0.01) and a lower detection rate of rtM204 V/I+M250 V/I/L substitution (0.67% vs. 1.46%, p < 0.01).

Analysis of the prevalence of drug-resistant hepatitis B virus in patients with antiviral therapy failure in a Chinese tertiary referral liver centre (2010-2014).

PMID: 28017671 2017 Journal of global antimicrobial resistance

Abstract: M204I, N236T and L180M+M204V+V173L/S202G were the most common substitutions for l-nucleoside (3TC and LdT), ADV and ETV genotypic resistant phenotypes, respectively.

The enrichment of HBV immune-escape mutations during nucleoside/nucleotide analogue therapy.

PMID: 28300730 2017 Antiviral therapy

Abstract: RESULTS: A total of 97 patients in the NA treatment group had resistance mutations, with rtM204I/V/S being the most common substitution (78 of 97), while no resistance mutations were detected in the treatment-naive group.

HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy.

PMID: 28303969 2017 Scientific reports

Result: Among these, sT114S, sA194V and sW196L corresponded to rtF/H122L, rtS202G and rtM204V respectively.

Result: Direct sequencing of the PCR amplified RT domain of HBV/D from 16 LMV-failed patients demonstrated the presence of well-known LMV resistance mutations, rtM204V/I, rtL180M, rtS202G,

Predominance of Hepatitis B Virus Genotype A Among Treated HIV Infected Patients Experiencing High Hepatitis B Virus Drug Resistance in Nairobi, Kenya.

PMID: 28316253 2017 AIDS research and human retroviruses

Abstract: Five subjects had rtV173L, rtL180M, and rtM204V and one with rtL180M and rtM204V major mutations.

Clinical features and viral quasispecies characteristics associated with infection by the hepatitis B virus G145R immune escape mutant.

PMID: 28325923 2017 Emerging microbes & infections

Result: We also screened several mutations relevant to antiviral resistance, such as I169L, L180M, A181V, T184I, S202C, M204V/I, N236T and M250I in the RT region.

Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy.

PMID: 28392234 2017 Journal of hepatology

3Introduction: The molecular explanation is that ETV resistance usually requires the LAM-resistant ""YMDD mutation(s)"" (rtM204V/I +-L180M) plus an additional ETV 'signature' substitution in the B domain (rtI169T or rtS184G), C

Result: Other mutations, especially those related to LAM or ETV resistance (rtL180M and rtM204V/I) and classical immune escape (sG145R and/or P120T) variants were noted at no or very low frequencies (Table 1), despite ETV treatment.

Detection of Hepatitis B Virus M204I Mutation by Quantum Dot-Labeled DNA Probe.

PMID: 28445403 2017 Sensors (Basel, Switzerland)

Result: In order to further verify the accuracy of the new method, we employed PCR to detect these two samples, and the results confirmed that the two samples did contain the HBV M204V mutation, suggesting that the accuracy of the serum HBV DNA extraction combined with QDs-mediated fluorescent method was higher than that of the direct sequencing method.

Result: We also used the new method to detect the above serum samples and found that the abovementioned 11 samples were again detected to be M204I mutations-positive samples, while two serum samples of the 17 mutation-negative samples were in fact detected to be M204V mutations-positive samples, which were thus inconsistent with the results of direct sequencing.

Mutations associated with drug resistance and prevalence of vaccine escape mutations in patients with chronic hepatitis B infection.

PMID: 28500726 2017 Journal of medical virology

Abstract: Six patients (7%) exhibited resistance mutations to LAM, ETV, and TDF: two with patterns L180M + M204V and four with other different patterns: L80I + L180M + M204I; L80V + L180M + M204V; M204I; A194T.

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