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 HBV mutation literature information.


  HIV therapy with unknown HBV status is responsible for higher rate of HBV genome variability in Ethiopia.
 PMID: 27354181       2017       Antiviral therapy
Abstract: Despite the finding that rtL180M and rtM204V/I were higher among ART-experienced individuals, the overall prevalence of DRMs (48.0% versus 36.4%) showed no significance difference among antiretroviral therapy (ART) status.
Abstract: Lamivudine selected DRMs, that is, rtL180M (29.3%) and rtM204V/I (29.3%) and rtV173L (15.5%) were more prevalent in HBV-HIV-coinfected individuals but absent in HBV-monoinfected individuals.
Abstract: RESULTS: In 34 out of 161 study subjects (21.1%) HBV drug resistance mutations (DRM


  Comparison of Detection Rate and Mutational Pattern of Drug-Resistant Mutations Between a Large Cohort of Genotype B and Genotype C Hepatitis B Virus-Infected Patients in North China.
 PMID: 27792585       2017       Microbial drug resistance (Larchmont, N.Y.)
Abstract: For entecavir-resistant mutations, HBV/C-infected patients had a higher detection rate of rtM204 V/I+T184 substitution or S202G/C (3.66% vs. 2.16%, p < 0.01) and a lower detection rate of rtM204 V/I+M250 V/I/L substitution (0.67% vs. 1.46%, p < 0.01).


  Analysis of the prevalence of drug-resistant hepatitis B virus in patients with antiviral therapy failure in a Chinese tertiary referral liver centre (2010-2014).
 PMID: 28017671       2017       Journal of global antimicrobial resistance
Abstract: M204I, N236T and L180M+M204V+V173L/S202G were the most common substitutions for l-nucleoside (3TC and LdT), ADV and ETV genotypic resistant phenotypes, respectively.


  The enrichment of HBV immune-escape mutations during nucleoside/nucleotide analogue therapy.
 PMID: 28300730       2017       Antiviral therapy
Abstract: RESULTS: A total of 97 patients in the NA treatment group had resistance mutations, with rtM204I/V/S being the most common substitution (78 of 97), while no resistance mutations were detected in the treatment-naive group.


  HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy.
 PMID: 28303969       2017       Scientific reports
Discussion: A previous study from North India reported the presence of rtM204V/I resistant mutants in 6% and 29% CHB patients receiving LMV for 12 and 18 months respectively while another study from South India detected M204V/I mutations in 27% of LMV-treated patients after a median treatment period of 13 months.
Discussion: Following TDF therapy, the frequencies of rt
Discussion: documented that HBV bearing the rtM204V + rtL180M mutations displayed a 3.33 and 2.1-fold increase in the IC50 for TDF compared to wild-type virus in cell culture suggesting that TDF was less efficacious on these LMV-resistant mutants.


  Predominance of Hepatitis B Virus Genotype A Among Treated HIV Infected Patients Experiencing High Hepatitis B Virus Drug Resistance in Nairobi, Kenya.
 PMID: 28316253       2017       AIDS research and human retroviruses
Abstract: Five subjects had rtV173L, rtL180M, and rtM204V and one with rtL180M and rtM204V major mutations.


  Clinical features and viral quasispecies characteristics associated with infection by the hepatitis B virus G145R immune escape mutant.
 PMID: 28325923       2017       Emerging microbes & infections
Result: We also screened several mutations relevant to antiviral resistance, such as I169L, L180M, A181V, T184I, S202C, M204V/I, N236T and M250I in the RT region.


  Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy.
 PMID: 28392234       2017       Journal of hepatology
3Introduction: The molecular explanation is that ETV resistance usually requires the LAM-resistant ""YMDD mutation(s)"" (rtM204V/I +-L180M) plus an additional ETV 'signature' substitution in the B domain (rtI169T or rtS184G), C domain (rtS202G/I), or E domain (rtM250V)."
Discussion: The presence of rtS78T in addition to rtT184S, rtV173L,  PMID: 28445403       2017       Sensors (Basel, Switzerland)
Result: In order to further verify the accuracy of the new method, we employed PCR to detect these two samples, and the results confirmed that the two samples did contain the HBV M204V mutation, suggesting that the accuracy of the serum HBV DNA extraction combined with QDs-mediated fluorescent method was higher than that of the direct sequencing method.
Result: We also used the new method to detect the above serum samples and found that the abovementioned 11 samples were again detected to be M204I mutations-positive samples, while two serum samples of the 17 mutation-negative samples were in fact detected to be M204V mutations-positive samples, which were thus inconsistent with the results of direct sequencing.


  Mutations associated with drug resistance and prevalence of vaccine escape mutations in patients with chronic hepatitis B infection.
 PMID: 28500726       2017       Journal of medical virology
Abstract: Six patients (7%) exhibited resistance mutations to LAM, ETV, and TDF: two with patterns L180M + M204V and four with other different patterns: L80I + L180M + M204I; L80V + L180M + M204V; M204I; A194T.



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