Prevalence of mutations in HBV DNA polymerase gene associated with nucleos(t)ide resistance in treatment-naive patients with Chronic Hepatitis B in Central China.
PMID: 26876337
2016
The Brazilian journal of infectious diseases
Abstract: Mutations in HBV DNA polymerase were detected in 24 patients (8.9%) including rtM204I/V (n=6), rtN236T (n=5), rtM250V (n=2), rtL180M (n=2), rtT184G (n=1), rtM207I (n=1), rtS202I (n=1), rtM204V/I & rtL180M (n=5), and rtM204I &
Dynamics of Genotypic Mutations of the Hepatitis B Virus Associated With Long-Term Entecavir Treatment Determined With Ultradeep Pyrosequencing: A Retrospective Observational Study.
Result: At baseline, this patient displayed rtM204I/V (3.5%), rtL180 M (2.1%), and rtS202G (3.4%) substitutions, and the resistance and nonresistance mutations frequencies were significantly different (P = 0.011).
Result: Eight patients harbored rtM204I/V substitutions of at least 1% (ranging from 1% to 3.6%); 2 of these patients also presented rtL180 M substitutions (2.3% and 2.4%) and rtS202G substitutions (3.2% and 3.5%), whereas the other 6 harbored a low frequency of rtS202G substitut
Broad Range of Hepatitis B Virus (HBV) Patterns, Dual Circulation of Quasi-Subgenotype A3 and HBV/E and Heterogeneous HBV Mutations in HIV-Positive Patients in Gabon.
Abstract: The mutation M204V/I conferring resistance to 3TC was more common in HBV/A (47.4%) than in HBV/E isolates (0%) (P = .04).
Introduction: Regarding HBV mutations, the use of 3TC alone has been shown to be strongly associated with consistently high HBV viremia due to the rapid emergence of HBV mutants carrying the M204I/V mutation conferring resistance to 3TC/FTC.
Method: Using th
Discussion: Importantly, we identified in our survey three natural M204V/I mutations in 3TC-naive patients, as already described in other settings.
Discussion: Third, the M204V/I RAM were more common in HBV/A strains.
Discussion: When considering HBV/A genotypes only, we observed a high (~50%) prevalence of M204V/I and L180M mutations.
Evaluation of the dynamic pattern of viral evolution in patients with virological breakthrough during treatment with nucleoside/nucleotide analogs by ultradeep pyrosequencing.
Result: In all four patients, the M204V mutation was accompanied by the L180M mutation, and an identical trend was observed in the two mutation sites (Table III).
Result: Notably, the mutation rate of rtM204I/V was markedly increased at the time of virological breakthrough in eight patients, and this was accompanied by an increased mutation rate of rtL180M and/or rtL80I/V.
Result: the M204V mutation in patients E and F eventually disappeared following the ADV add-on therapy, which also occurred in the other two patients.
Discussion: Additionally, the present study revealed that YVDD-variant-dominated virological bre
Effect of tenofovir disoproxil fumarate on drug-resistant HBV clones.
Abstract: RESULTS: TDF susceptibilities of lamivudine-resistant clones (rtL180M/M204V) and lamivudine plus entecavir-resistant clones (rtL180M/S202G/M204V) were similar to wild type clones in vitro.
Combined Analysis of the Prevalence of Drug-Resistant Hepatitis B Virus in Antiviral Therapy-Experienced Patients in Europe (CAPRE).
PMID: 26136470
2016
The Journal of infectious diseases
Abstract: The most frequently encountered primary mutation was M204V/I (48.7%), followed by A181T/V (3.8%) and N236T (2.6%).
Tenofovir monotherapy versus tenofovir and entecavir combination therapy in patients with entecavir-resistant chronic hepatitis B with multiple drug failure: results of a randomised trial.
Abstract: All patients had at least one ETV-resistance mutation: rtT184A/C/F/G/I/L/S (n=49), rtS202G (n=43) and rtM250L/V (n=7), in addition to rtM204V/I (n=90).
Investigation by the Method of INNO-LiPA of Primary Resistance to Lamivudine in Patients with Chronic Hepatitis B Who Have Not Used Antiviral Therapy.
PMID: 26901602
2015
The West Indian medical journal
Abstract: The rtM204V and L180M mutation motif was found in one patient with HBeAg positivity.
GENOMIC ANALYSIS OF HEPATITIS B VIRUS STRAINS INFECTING ROMANIAN PATIENTS.
PMID: 26727850
2015
Roumanian archives of microbiology and immunology
Abstract: Two patients treated with lamivudine were found to carry isolates harboring rtM204V lamivudine resistance mutation.
Epidemiology study of HBV genotypes and antiviral drug resistance in multi-ethnic regions from Western China.
Introduction: Combination of rtM204V/I, rtL180M plus one of the following mutations: rtT184S/C/I/A, rtS202G/C/I or
Discussion: In this study, we did not find any statistical difference in the frequency of rtM204V and rtM204I between genotype B and C (P = 0.119, P = 0.161, respectively) in LMV-resistant patients as well.
Discussion: revealed that rtM204V was selected more frequently in genotype A patients compared to non-genotype A patients.
HBV mutation literature information.
PMID: 
2016
The Brazilian journal of infectious diseases
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