Abstract: The data showed different compensatory changes followed by the rtM204I/V.
Result: Among these sites, the rtL180 M came along with rtM204I/V as previous reports, but here we noticed it was not along with rtM204I in genotype B and majority of genotype C.
Result: Interestingly, their converted ratios were always lower than that of rtM204I/V itself.
Result: Taken together, it reflected that the co-variance went through several steps during the evolutionary process, and the multiple-sites combined co-variance trended to an ideal state after rt
Pre-existing mutations related to tenofovir in chronic hepatitis B patients with long-term nucleos(t)ide analogue drugs treatment by ultra-deep pyrosequencing.
Discussion: In one article, the most commonly detected mutations were M204V/I(9/14) and M250V/I(11/14); other documented mutations include A181T/V(7/14) and N236T(3/14).
Discussion: The virus communities in patients 1 and 2 harbored the A181T/V(4.7%/4.7%), N236T(6%/5.7%), L180M(2.4%/12.5%) and M204I/V(3.4%/7%), while those in patients 3 and 4 harbored only the A181T/V(1.4%/1.2%), and N236T(1.8%/1.4%).
Discussion: They harbor the A181T/V(1.2%/8.7%) and N236T(1.8%/1.7%) substitutions; that of patient 6 harbored the
Monitoring of genotypic resistance profile in chronic hepatitis B patients receiving nucleos(t)ide analogues in Huzhou, China.
PMID: 27694733
2016
Journal of infection in developing countries
Abstract: Among patients who harbored rtM204 combination mutations, rtM204I and rtM204V were significantly associated with rtL80I/V and rtL180M, respectively.
Serologic and genotypic characterization of hepatitis B virus in HIV-1 infected patients from South West and Littoral Regions of Cameroon.
Result: Mutations rtV173L, rtL180M, rtM204V conferring resistance to lamivudine and other L-nucleoside analogues were identified in six patients while one patient had the rtL180M + rtM204V + rtT184S mutations associated with resistance to both L-nucleoside analogues and entecavir.
Table: M204V
Discussion: The mutation rtL180M found together with the rtM204V mutation in these patients is
Comparative evaluation of long-term monotherapies & combination therapies in patients with chronic hepatitis B: A pilot study.
PMID: 28139541
2016
The Indian journal of medical research
Abstract: Mutations: rtM204V (39.3%), M204V+L180M (10.7%) while rtA181V (8.1%) and rtN236T (8.3%) were observed with LAM and ADV regimen, respectively.
Result: Mutation in the YMDD,
Discussion: M204V substitution was already reported earlier.
Discussion: In addition, there was another compensatory mutation i.e., L180M + M204V.
Discussion: In all patients on LAM therapy, the site of mutation was methionine in the YMDD motif for valine i.e., M204V at the end of second year.
Betaine Inhibits Hepatitis B Virus with an Advantage of Decreasing Resistance to Lamivudine and Interferon alpha.
PMID: 27144395
2016
Journal of agricultural and food chemistry
Abstract: BET suppressed HBV DNA rebound produced by the resistance of HBV to lamivudine and decreased the resistance mutation (rtM204V/I) of HBV DNA.
De novo entecavir+adefovir dipivoxil+lamivudine triple-resistance mutations resulting from sequential therapy with adefovir dipivoxil, and lamivudine.
PMID: 27079793
2016
Annals of clinical microbiology and antimicrobials
Abstract: Specifically, we found one rtM204I+rtL180 M+rtM250 V+rtA181 V clone among 23 clones from patient 1 (4.35 %), one rtM204 V+vrtL180 M +rtM250 V+rtA181 V clone among 24 clones from patient 2 (4.17 %), and 2 clones harboring rtM204 V+rtL180 M+rtM250 V+rt
Higher detection rates of amino acid substitutions in HBV reverse transcriptase/surface protein overlapping sequence is correlated with lower serum HBV DNA and HBsAg levels in HBeAg-positive chronic hepatitis B patients with subgenotype B2.
PMID: 27006281
2016
Infection, genetics and evolution
Abstract: In addition, two patients harboring drug resistance mutations rtL80V+rtM204I and rtL180M+rtM204V were found.
Evolution of entecavir-resistant hepatitis B virus during entecavir and adefovir dipivoxil combination therapy.
PMID: 26889227
2016
Experimental and therapeutic medicine
Abstract: Clonal analysis further revealed that the rtS202G or rtT184F was in all cases co-localized with rtL180M and rtM204V in any single virus isolate clone.
Abstract: In patient A, the rtL180M, rtS202G and rtM204V mutant variants were detected using pyrosequencing prior to virological breakthrough.
HBV mutation literature information.
PMID: 
2016
Journal of virological methods
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