literature

HBV mutation literature information.

Hepatitis B in the Northwestern region of Sao Paulo State: genotypes and resistance mutations.

PMID: 34755817 2021 Revista do Instituto de Medicina Tropical de Sao Paulo

Abstract: Resistance mutations (rtM204V/I/S) associated or not with compensatory mutations (rtL180M, rtV173L) were identified in 13.9% (5/36) of patients undergoing viral treatment and 1.1% (1/90) of naive patients.

Result: In the group of patients undergoing treatment, strains of HBV with resistance mutations (rtM204V/I/S) associated or not with compensatory mutations (rtL180M, rtV173L) were identified in 13.9% (5/36) of the analyzed samples.

Result: In the group of patients who were not undergoing treatment, 1.1% (1/90) of the samples pr

Hepatitis B virus genetic heterogeneity and drug resistance among jaundiced patients at Coast General Teaching and Referral Hospital, Mombasa County, Kenya.

PMID: 34234632 2021 International journal of health sciences

Abstract: Six patients (13.3%) had rtV173L, rtL180M, and rtM204V mutations; five subjects (11.1%) with rtL180M and rtM204V while 1 patient (2.2%) had rtM204V mutations.

Result: Mutation rtM204V conferring resistance to 3CT occurred predominantly at 26.7% in all the patients followed by rtL180M (20.0%) and rtV173L at 13.3%.

Result: On the other hand, 5

rt269I Type of Hepatitis B Virus (HBV) Polymerase versus rt269L Is More Prone to Mutations within HBV Genome in Chronic Patients Infected with Genotype C2: Evidence from Analysis of Full HBV Genotype C2 Genome.

PMID: 33803998 2021 Microorganisms

Discussion: Indeed, we found several rt269I signature mutation types related to lower HBV replication (I84T/M/L/V in PreS1, preC-W28Stop, V/L5M in X region, C-I97F/L in C region and rtM204I/V in RT region) or liver disease progression (three types in preC/C region (preC-W28Stop, C-

The Occurrence of rtA194T Mutant After Long-Term Lamivudine Monotherapy Remains Sensitive to Tenofovir Disoproxil Fumarate: A Case Report.

PMID: 33758517 2021 Infection and drug resistance

Abstract: We present here a 62-year-old CHB patient who occurred rtL180M, rtM204V and rtA194T mutants after lamivudine (LAM) monotherapy for 9 years.

Discussion: Apart from rtL180M, rtM204V and rtA194T mutations, rtM187V and rtV207L were also detected.

Discussion: Interestingly, genotypic drug resistance testing showed that rt

Multiple drug-resistant HBV mutation may contribute to poor response of adefovir + entecavir in entecavir-resistant patients.

PMID: 33571155 2021 Journal of infection in developing countries

Abstract: RESULTS: ETV-resistant mutants were continuously detected in 10 of the 12 patients, and multidrug-resistant (MDR) mutants, including a novel strain (rtL180M+A181V+T184A+S202G+M204V), were detected in two patients.

Distinctive HBV Replication Capacity and Susceptibility to Tenofovir Induced by a Polymerase Point Mutation in Hepatoma Cell Lines and Primary Human Hepatocytes.

PMID: 33562603 2021 International journal of molecular sciences

Discussion: Nevertheless, some recent studies have shown that rtS78T/sC69*, rtS106C/rtH126Y/rtD134E/rtL269I, and rtL180M/T184L/M204V/rtA200V are related to TDF resistance.

Virologic analysis of tenofovir resistance in a patient with chronic hepatitis B experiencing viral breakthrough during combination treatment with tenofovir disoproxil fumarate and entecavir.

PMID: 33462964 2021 Hepatology research

Abstract: A recent Korean report showed that two patients with viral breakthrough during treatment with TDF-containing regimens were found to carry five reverse transcriptase (rt) mutations ([rt]S106C[C], rtH126Y[Y], rtD134E[E], rtM204I/V, and rtL269I [I]), with the C, Y, E, and I mutations being associated with tenofovir resistance.

Abstract: Four mutations (rtS106C, rtD134N/S[N/S], rt

Prevalence and characteristics of hepatitis B and D virus infections among HIV-positive individuals in Southwestern Nigeria.

PMID: 33446224 2021 Virology journal

Abstract: HBV DRMs V173L, L180M, S202I and M204V/I, which are associated with lamivudine resistance, were detected in 32.2% (n = 10/31) of the HBV DNA-positive samples.

Discussion: Amino acid (aa) substitutions found in this study include rtL180M, rtV173L, rtM204V/I among individuals on ART however, in one drug-naive individual, aa substitutions L180M, M204V and S202I have also been detected.

Discussion: Here, we found a high prevalence of resistance mutations to nucleoside analogues and predominantly mutations usua

Identification of a novel long-acting 4'-modified nucleoside reverse transcriptase inhibitor against HBV.

PMID: 33333207 2021 Journal of hepatology

Abstract: E-CFCP also reduced HBVETV-RL180M/S202G/M204V-viremia by 2 logs over 2 weeks, while ETV completely failed to reduce HBVETV-RL180M/S202G/M204V-viremia.

Abstract: RESULTS: E-CFCP potently blocked HBVWTD1 production (IC50qPCR_cell=1.8 nM) in HepG2.2.15 cells and HBVWTC2 (IC50SB_cell=0.7 nM), entecavir (ETV)-resistant HBVETV-RL180M/S202G/M204V (IC50SB_cell=77.5 nM), and adefovir-resistant HBVADV-RA181T/N236T production (IC50SB_cell=14.1 nM) in Huh7 cells.

Rapid Turnover of Hepatitis B Virus Covalently Closed Circular DNA Indicated by Monitoring Emergence and Reversion of Signature-Mutation in Treated Chronic Hepatitis B Patients.

PMID: 32189364 2021 Hepatology (Baltimore, Md.)

Abstract: APPROACH AND RESULTS: In this study, we retrospectively monitored the emergence and reversion of the rtM204I/V mutant, a signature lamivudine resistance (LAMR ) mutation serving as a biomarker of cccDNA turnover in liver biopsies and longitudinal serum samples from two clinical trials.

Result: In addition, 5 patients with sustained HBeAg-positive and HBV DNA >3 log10 IU/mL until the end of the follow-up period, who presented 100% rtM204I/V mutation at baseline, were also included for kinetics analysis of rtM204I/V in serum HBV DNA/RNA during the interferon rescue period.

Result: In brief, for the EFFORT study, 299 patients were included in the MONO group and 77 of them developed VB as well as the

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