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 HBV mutation literature information.


  Clinical emergence of entecavir-resistant hepatitis B virus requires additional substitutions in virus already resistant to Lamivudine.
 PMID: 15328117       2004       Antimicrobial agents and chemotherapy
Abstract: For liver transplant patient B (AI463015-B), previous famciclovir, ganciclovir, foscarnet, and 3TC therapies had failed, and RT changes rtS78S/T, rtV173L, rtL180M, rtT184S, and rtM204V were present at study entry.
Abstract: The 3TC(r) RT substitutions rtV173L, rtL180M, and rtM204V were present at study entry, and the additional substitutions


  Oligonucleotide chip for detection of Lamivudine-resistant hepatitis B virus.
 PMID: 15365009       2004       Journal of clinical microbiology
Abstract: Among these, 17 contained rtM204V (YVDD), 24 contained rtM204I3 (YIDD3), 3 contained rtM204I2 (YIDD2), and 36 contained mixed types.


  Pyrosequencing for detection of lamivudine-resistant hepatitis B virus.
 PMID: 15472342       2004       Journal of clinical microbiology
Abstract: Lamivudine-resistant HBV mutants display specific mutations in the YMDD (tyrosine, methionine, aspartate, aspartate) motif of the viral polymerase (reverse transcriptase [rt]), which is the catalytic site of the enzyme, i.e., methionine 204 to isoleucine (rtM204I) or valine (rtM204V).


  [Determination of hepatitis B virus genotype and detection of lamivudine-resistance mutations].
 PMID: 15544736       2004       Gastroenterologia y hepatologia
Abstract: Patients with genotype A showed the pattern M204I+WT in the first 12 months and those with genotype D showed the pattern L180M+M204V with or without WT at 18 months.


  Long-term therapy with lamivudine in renal transplant recipients with chronic hepatitis B.
 PMID: 15618847       2004       European journal of gastroenterology & hepatology
Abstract: Analysis of HBV sequencing after breakthrough revealed specific resistance mutations in both the B and C domains of the polymerase (rtL180M/M204V, n = 5; rtM204I, n = 2).


  Effect of the G1896A precore mutation on drug sensitivity and replication yield of lamivudine-resistant HBV in vitro.
 PMID: 12500185       2003       Hepatology (Baltimore, Md.)
Abstract: HBV baculoviruses encoding the G1896A PC stop codon mutation were generated in wild-type (WT) and lamivudine-resistant (rtM204I and rtL180M + rtM204V) backgrounds, resulting in a panel of 6 related recombinant baculoviruses.


  Lamivudine and Famciclovir resistant hepatitis B virus associated with fatal hepatic failure.
 PMID: 12727536       2003       Journal of clinical virology
Abstract: Subsequent to the instigation of antiviral therapy, the dominant drug resistant HBV which caused virological breakthrough and was associated with hepatic failure displayed a series of unique mutations particularly in the BCP (A1762T and G1764A) and in the polymerase (rtL180M, rtM204V, rtA222T and rtL336V), core (cP5T, cS26A,


  Generation of stable cell lines expressing Lamivudine-resistant hepatitis B virus for antiviral-compound screening.
 PMID: 12760870       2003       Antimicrobial agents and chemotherapy
Abstract: HBV produced by these cell lines was shown to have a marked decrease in sensitivity to lamivudine, with 450- and 3,000-fold shifts in the 50% inhibitory concentrations for the rtM204I and rtL180M/M204V viruses, respectively, compared to that for the wild-type virus.
Abstract: Replication-competent HBV constructs containing the reverse transcriptase domain L180M/M204V and M204I (rtL180M/M204V and rtM204I) mutations associated with lamivudine resistance were used to produce stable cell lines t


  Characterization of hepatitis B virus surface antigen and polymerase mutations in liver transplant recipients pre- and post-transplant.
 PMID: 12780567       2003       American journal of transplantation
Abstract: Significant viral polymerase mutations (rtL180M and rtM204I/V) also emerged in all of these patients following treatment with lamivudine and/or famciclovir.


  YSDD: a novel mutation in HBV DNA polymerase confers clinical resistance to lamivudine.
 PMID: 12823591       2003       Journal of viral hepatitis
Abstract: Of the seven patients, six were HBeAg positive at baseline, and four had a double mutation consisting of rtM204V and rtL180M, while two had an rtM204I change.



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