literature

HBV mutation literature information.

Inhibitory effect of Phyllanthus urinaria L. extract on the replication of lamivudine-resistant hepatitis B virus in vitro.

PMID: 26220282 2015 BMC complementary and alternative medicine

Abstract: METHODS: HBV harboring LMV-resistant mutations (rtM204I, rtM204V, and rtM204S) in the P gene at the YMDD ((203)tyrosine-methionine-aspartate-aspartate(206)) reverse transcriptase (RT) active site were generated and their sensitivity to

Introduction: The most common mutation associated with LMV resistance is the substitution of methionine 204 with isoleucine, valine, or serine (M204I/V/S) at the YMDD active site motif within the P protein RT domain.

rtM204Q may serve as a novel lamivudine-resistance-associated mutation of hepatitis B virus.

PMID: 24586482 2014 PloS one

Introduction: Signature LAM resistance mutations have been mapped to the tyrosine-methionine-aspartate-aspartate (YMDD) locus in the catalytic or C domain of HBV reverse transcriptase (RT) region, and the primary resistance mutations are isoleucine (I), valine (V), or occasionally serine (S) that were designated <

Discussion: For the position of rt204 in the HBV RT region, rtM204V and rtM204I are well-known primary LAM- and/or LdT-resistant mutation, and rtM204S was also reported to be induced by LAM treatment and conferred LAM resistance.

Death from Liver Failure despite Lamivudine Prophylaxis during R-CHOP Chemotherapy due to Rapid Emergence M204 Mutations.

PMID: 25374716 2013 Case reports in hepatology

Abstract: ALT 902 IU/L, HBeAg negative, HBV DNA 1.02E8 IU/mL, and genotyping confirmed L80I, M80V, and M204V/S mutations.

Conclusion: Genotyping with the INNO-LIPA assay confirmed L80I, M80V, and M204V/S mutations, conferring lamivudine resistance.

Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients.

PMID: 22882650 2012 Liver international

Result: Among patients with lamivudine related resistance mutations, eleven had rtM204I/V/S (four with rtM204I, six with rtM204V and one with rtM204S), nine had rtL180M and three had rtV173L mutation.

Frequency and mutation patterns of resistance in patients with chronic hepatitis B infection treated with nucleos(t)ide analogs in add-on and switch strategies.

PMID: 22224083 2011 Hepatitis monthly

Introduction: Nine major mutation patterns associated with LAM resistance have been reported: (i) rtM204I/V + rtL180M; (ii) rtM204I; (iii) rtV173L + rtL180M + rtM204V; (iv) rtL80I + rtM204I; (v) rtQ215S + rtM204I/V +- rtL18

Multidrug-resistant hepatitis B virus strain in a chronic Turkish patient.

PMID: 22312387 2010 Hepatitis monthly

Introduction: Moreover, a few studies of Turkish patients with treated or untreated CHB infections have frequently indicated HBV drug resistance as rtM204V (YVDD variant), rtM204I (YIDD variant) and, rarely, as rtM204S (YSDD variant) mutations with or without compensatory mutations, such as rtV173L and rtL180M .

Mechanistic characterization and molecular modeling of hepatitis B virus polymerase resistance to entecavir.

PMID: 20169198 2010 PloS one

Discussion: Modeling studies suggest that the N236T change may indirectly affect binding of the terminal gamma-phosphate of adefovir-diphosphate and changes at A181 of the alpha helix adjacent to the YMDD active site loop likely affect the position of the YMDD loop itself or the nucleotide in the +1 position through interactions of A181V or T with the M204 S-methyl moiety of the YMDD loop.

Ultra-deep pyrosequencing of hepatitis B virus quasispecies from nucleoside and nucleotide reverse-transcriptase inhibitor (NRTI)-treated patients and NRTI-naive patients.

PMID: 19301976 2009 The Journal of infectious diseases

Method: Established NRTI-resistance mutations included the following RT mutations: rtL80V/I, rtI169T, rtV173L, rtL180M, rtA181TV, rtT184S/A/I/L/F/G, rtA194T, rtS202G/I, rtM204V/I/S, rtN236T, and rt

PMID: 17438047 2007 Antimicrobial agents and chemotherapy

Abstract: Mutations that result in the replacement of the methionine at position 204 of the deoxynucleoside triphosphate-binding site of the hepatitis B virus (HBV) reverse transcriptase (rt) by isoleucine, valine, or (rarely) serine (rtM204I/V/S) confer high-level resistance to LMV but reduce replication efficiency.

Identification of a new variant in the YMDD motif of the hepatitis B virus polymerase gene selected during lamivudine therapy.

PMID: 12171302 2002 Journal of medical microbiology

Abstract: A new hepatitis B virus variant selected during lamivudine treatment was detected, in which the methionine (rtM204) in the so-called YMDD motif in the C domain of the catalytic site of the polymerase gene was replaced by a serine (rtM204S).

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