literature

HBV mutation literature information.

Dynamics of Genotypic Mutations of the Hepatitis B Virus Associated With Long-Term Entecavir Treatment Determined With Ultradeep Pyrosequencing: A Retrospective Observational Study.

PMID: 26825915 2016 Medicine

Result: At baseline, this patient displayed rtM204I/V (3.5%), rtL180 M (2.1%), and rtS202G (3.4%) substitutions, and the resistance and nonresistance mutations frequencies were significantly different (P = 0.011).

Result: Eight patients harbored rtM204I/V substitutions of at least 1% (ranging from 1% to 3.6%); 2 of these patients also presented rtL180 M substitutions (2.3% and 2.4%) and rtS202G substitutions (3.2% and 3.5%), whereas the other 6 harbored a low frequency of rtS202G substitut

Broad Range of Hepatitis B Virus (HBV) Patterns, Dual Circulation of Quasi-Subgenotype A3 and HBV/E and Heterogeneous HBV Mutations in HIV-Positive Patients in Gabon.

PMID: 26764909 2016 PloS one

Abstract: The mutation M204V/I conferring resistance to 3TC was more common in HBV/A (47.4%) than in HBV/E isolates (0%) (P = .04).

Introduction: Regarding HBV mutations, the use of 3TC alone has been shown to be strongly associated with consistently high HBV viremia due to the rapid emergence of HBV mutants carrying the M204I/V mutation conferring resistance to 3TC/FTC.

Method: Using the Mutation Reporter Tool software (http://hvdr.bioinf.wits.ac.za/mrt/), HBV resistance-associated mutations (RAMs) in the pol gene represented by V173L, L180M, A181V, A194T, S202G, M204V/I and N236T were assessed.

Evaluation of the dynamic pattern of viral evolution in patients with virological breakthrough during treatment with nucleoside/nucleotide analogs by ultradeep pyrosequencing.

PMID: 26648309 2016 Molecular medicine reports

Result: Although all 12 patients experienced viral breakthrough during the treatment with LAM, low rates of drug resistance-associated mutations were observed at week 0 prior to the treatment, with the exception of patient D, who exhibited a rate of 94.03 for M204I, and patient G, who exhibited a rate of 97.59 for A181V.

Result: Furthermore, the increased mutation rate of rt180 or rt80 was accompanied by the occurrence of the high mutation rate of M204I during the virological breakthrough.

Result: Notably, the mutation rate of rtM204I/V was markedly increased at the time of virological breakthrough in eight patients, and this was accompanied by an increased mutation rate of rt

Combined Analysis of the Prevalence of Drug-Resistant Hepatitis B Virus in Antiviral Therapy-Experienced Patients in Europe (CAPRE).

PMID: 26136470 2016 The Journal of infectious diseases

Abstract: The most frequently encountered primary mutation was M204V/I (48.7%), followed by A181T/V (3.8%) and N236T (2.6%).

Tenofovir monotherapy versus tenofovir and entecavir combination therapy in patients with entecavir-resistant chronic hepatitis B with multiple drug failure: results of a randomised trial.

PMID: 25596179 2016 Gut

Abstract: All patients had at least one ETV-resistance mutation: rtT184A/C/F/G/I/L/S (n=49), rtS202G (n=43) and rtM250L/V (n=7), in addition to rtM204V/I (n=90).

GENOMIC ANALYSIS OF HEPATITIS B VIRUS STRAINS INFECTING ROMANIAN PATIENTS.

PMID: 26727850 2015 Roumanian archives of microbiology and immunology

Abstract: An HBV isolate displaying a lamivudine complex resistance pattern, rtM204I in conjunction with rtL180M and rtA200V, was found in a lamivudine naive patient.

Epidemiology study of HBV genotypes and antiviral drug resistance in multi-ethnic regions from Western China.

PMID: 26612031 2015 Scientific reports

Introduction: Combination of rtM204V/I, rtL180M plus one of the following mutations: rtT184S/C/I/A, rtS202G/C/I or rtM250V links to ETV resistance.

Introduction: Two large-scale clinical studies from China found that rtM204I with or without rtL180V was more frequent in genotype C than genotype B.

Discussion: Another L-Nucleoside, LdT, shared some similar amino acid substitution in polymerase with LMV, namely

Composition and Interactions of Hepatitis B Virus Quasispecies Defined the Virological Response During Telbivudine Therapy.

PMID: 26599443 2015 Scientific reports

Discussion: Additionally, once the rtM204I mutant prevailed over the rtA181T and wild-type viruses, we observed that VB developed quickly and that rtM204I predominated among the viral quasispecies, supporting the argument that the rtM204I mutant may have greater fitness than the rtA181T mutant under LdT treatment.

Discussion: Although we could not completely rule out the possibility that rtA181T and rtM204I simultaneously exist in the same genome due to the limited sequencing coverage in this study, o

Virological Characteristics of Acute Hepatitis B in Eastern India: Critical Differences with Chronic Infection.

PMID: 26571502 2015 PloS one

Result: There were no drug resistant mutations (lamivudine-resistant pattern: rtM204V/I, rtL180M, rtV173L, adefovir-resistant pattern: rtA181V/T, tenofovir-resistant pattern: rtA194T and entecavir-resistant pattern: rtL180M, rtS202G, rtM204V) detectable in acute patients belonging to our study population.

[Variability of Reverse Transcriptase Gene and S Gene in Lamivudine-treated Chronic Hepatitis B Patients].

PMID: 26524917 2015 Bing du xue bao

Abstract: rtL80I was present in most of the patients with rtM204I (14/20, 70%).

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