literature

Global prevalence and phylogeny of hepatitis B virus (HBV) drug and vaccine resistance mutations.

PMID: 33893696 2021 Journal of viral hepatitis

Abstract: RAM M204I/V had the highest prevalence, occurring in 3.8% (109/2838) of all HBV sequences in our data set, and a significantly higher rate in genotype C at 5.4% (60/1102, p = 0.0007).

Discussion: A previous meta-analysis estimated the prevalence of M204I/V as 4.9% among >12,000 treatment-naive individuals, and another review reported a prevalence of M204I/V of 5.9% among 8435 treatment-naive individuals.

Discussion: For example, RAMs in HBV reverse transcriptase, A181T/V, M204I and M204V, cause corresponding changes in the overlapping region of HBsAg (W172 stop, W196S/L/Stop and

PMID: 33803998 2021 Microorganisms

Discussion: Indeed, we found several rt269I signature mutation types related to lower HBV replication (I84T/M/L/V in PreS1, preC-W28Stop, V/L5M in X region, C-I97F/L in C region and rtM204I/V in RT region) or liver disease progression (three types in preC/C region (preC-W28Stop, C-

The Occurrence of rtA194T Mutant After Long-Term Lamivudine Monotherapy Remains Sensitive to Tenofovir Disoproxil Fumarate: A Case Report.

PMID: 33758517 2021 Infection and drug resistance

Discussion: Three mutations associated with LAM resistance have been mostly described: rtM204V/I in C domain, rtV173L and rtL180M in B domain.

Virologic analysis of tenofovir resistance in a patient with chronic hepatitis B experiencing viral breakthrough during combination treatment with tenofovir disoproxil fumarate and entecavir.

PMID: 33462964 2021 Hepatology research

Abstract: A recent Korean report showed that two patients with viral breakthrough during treatment with TDF-containing regimens were found to carry five reverse transcriptase (rt) mutations ([rt]S106C[C], rtH126Y[Y], rtD134E[E], rtM204I/V, and rtL269I [I]), with the C, Y, E, and I mutations being associated with tenofovir resistance.

Prevalence and characteristics of hepatitis B and D virus infections among HIV-positive individuals in Southwestern Nigeria.

PMID: 33446224 2021 Virology journal

Result: Amino acid substitutions were detected in the following frequency: rtM204V/I (9/31; 29.0%), rtL180M (8/31; 25.8%), rtV173L (7/31; 22.5%).

Result: No single mutation was detected while all amino acid substitutions were detected in combinations as rtL180M + rtV173L + rtM204V (n = 7/10), rtV173L + rtM204V (1/10), rtL180M +

PMID: 32189364 2021 Hepatology (Baltimore, Md.)

Abstract: APPROACH AND RESULTS: In this study, we retrospectively monitored the emergence and reversion of the rtM204I/V mutant, a signature lamivudine resistance (LAMR ) mutation serving as a biomarker of cccDNA turnover in liver biopsies and longitudinal serum samples from two clinical trials.

Result: In addition, 5 patients with sustained HBeAg-positive and HBV DNA >3 log10 IU/mL until the end of the follow-up period, who presented 100% rtM204I/V mutation at baseline, were also included for kinetics analysis of rtM204I/V in serum HBV DNA/RNA during the interferon rescue period.

Result: In brief, for the EFFORT study, 299 patients were included in the MONO group and 77 of them developed VB as well as the

Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations.

PMID: 32994690 2020 World journal of gastroenterology

Method: The eight strains were: WT, sA159V (M1), rtM204I (M2), sA159V+

Discussion: A phylogenetic analysis of Patient A-derived viral strains showed that sA159V+rtM204I (rtL180M) and sA159V+rtM204V (rtL180M) mutants are likely derived from the sA159V mutant as an adaptation to LAM pressure.

Mutational characterization of HBV reverse transcriptase gene and the genotype-phenotype correlation of antiviral resistance among Chinese chronic hepatitis B patients.

PMID: 33124952 2020 Emerging microbes & infections

Table: M204I

Figure: Small red arrows reflect the site of primary and secondary resistance mutations, from bottom to top: rtL180M, rtA181V/T/I, rtT184S/L, rtM204V/I, rtN236T/I.

Discussion: It was described in several reports that rtL229 mutants, mainly involving rtL229F and rtL229W, conferred resistance to LMV and showed a capacity of restored viral replication in vitro when coexisted with

Hepatitis B virus drug resistance mutations in HIV/HBV co-infected children in Windhoek, Namibia.

PMID: 32915862 2020 PloS one

Abstract: Resistance mutations included rtL80I, rtV173L, rtL180M, rtM204I/V and the overlapping sE164D, sW182*, sI195M and sW196LS variants.

Result: Amino acid changes including rtL80I, rtV173L, rt

Table: M204I

Comprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Region.

PMID: 33381105 2020 Frontiers in microbiology

Method: According to the most recent clinical practice guidelines of the European Association for the Study of the Liver, the following amino acid substitution profiles for HBV

Result: Overall, rtL180M, rtA181T/V, rtT184G/S, rtS202G/I, rtM204I, rtM204V, rtN236T, and rtM250V were more frequently detected in genotypes A (13.9%), C (0.8%), D (0.1%), H (3.8%), G (25%), A (13.1%), B (0.7%), and C (0.1%), respectively.