Amino acid similarities and divergences in the small surface proteins of genotype C hepatitis B viruses between nucleos(t)ide analogue-naive and lamivudine-treated patients with chronic hepatitis B.
Abstract: With little influence on immune escape-associated mutation frequencies within 'a' determinant, LMV-monotherapy significantly induced classical LMVr-associated mirror changes sE164D/rtV173L, sI195M/rtM204V and sW196L/S/rtM204I, as well as non-classical ones sG44E/rtS53N, sT47K/A/rt
Short duration of lamivudine for the prevention of hepatitis B virus transmission in pregnancy: lack of potency and selection of resistance mutations.
Abstract: UDPS showed that LMV therapy resulted in increased viral quasispecies diversity and positive selection of HBV variants with reverse transcriptase amino acid substitutions at sites associated with primary LMV resistance (rtM204I/V and rtA181T) in four (19%) women.
Randomized comparison of tenofovir disoproxil fumarate vs emtricitabine and tenofovir disoproxil fumarate in patients with lamivudine-resistant chronic hepatitis B.
Abstract: Patients were hepatitis B e antigen (HBeAg)-positive or HBeAg-negative, with levels of HBV DNA >=3 log10 IU/mL and lamivudine resistance mutations (HBV polymerase or reverse transcriptase amino acid substitutions rtM204I/V +- rtL180M by INNO-LiPA Multi-DR v3; Innogenetics, Inc, Alpharetta, GA).
Rapid detection of hepatitis B virus variants associated with lamivudine and adefovir resistance by multiplex ligation-dependent probe amplification combined with real-time PCR.
PMID: 24478474
2014
Journal of clinical microbiology
Abstract: Based on the results of MLP-RT-PCR, the mutations rtM204V, rtM204I, rtA181T, rtA181V, and rtN236T were 95.7% (111/116 patients), 98.3% (114/116 patients), 99.1% (115/116 patients), 98.3% (114/116 patients), and 99.1% (115/116 patients) concordant, respectively, with those of direct sequencing.
Abstract: For this study, a multiplex ligation-dependent probe real-time PCR (MLP-RT-PCR) method was developed to simultaneously detect lamivudine (LAM)- and adefovir (ADV)-resistant HBV mutants (those with the mutations rtM204V/I, rt
Drug-resistance associated mutations in polymerase (p) gene of hepatitis B virus isolated from malaysian HBV carriers.
Abstract: A number of significant drug resistant mutations were found in five patients including S202I, N236T, M250L, L180M/V, M204I, A181T, T184G, M250V, and V173L.
Abstract: Of these, L180M/V and M204I were most frequently detected (80%) and associated with lamivudine in combination with emtricitabine and telbivudine drug resistance.
Introduction: The most common mutation involved substitution of methionine for valine or isoleucine rtM204V/I.
Table: M204I
Dis
rtM204Q may serve as a novel lamivudine-resistance-associated mutation of hepatitis B virus.
Result: By contrast, rtM204I/rtM204V was detected in 2,502 patients with an incidence of 25.5% (2,502/9,830).
Result: Clonal sequencing (35 clones) of the sample at months 24 (Sa3) showed that rtM204Q, rtA181T, rtM204I, rtA181T+M204Q and wild-type strains occupied 14%, 14%, 3%, 0%, and 69%, respectively.
Result: Clonal sequencing (37 clones) of the sample at this point (Sa2) showed coexistence of rtM204Q (30%), rt
Establishment of real time allele specific locked nucleic acid quantitative PCR for detection of HBV YIDD (ATT) mutation and evaluation of its application.
Result: The two others, LDA173 and LDA339, displayed the lamivudine resistance triple mutation rtV173L, rtL180M, rtM204V/I which causes the concomitant amino acid substitutions E164D/G and I195M in the small S protein (Table 3).
Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma.
Result: It is worth noting that we did not observe any of the common NA-related resistance mutations including rtM204V/I, rtS202C/G/I, rtL180M, rtA181T/V, rtT184A/I/L/G/C/M, rtA194T, rtI169T, rtV173L, rtL80I, rtN236T, and PMID: 24790911
2014
Annals of laboratory medicine
Result: The rtM204I/V mutation (50.2%) was most frequently detected, followed by rtL180M (39.2%) and rtA181V/T (19.6%) mutations.
Result: There was no statistical difference of HBeAg positive rates among rtM204V, rtL180M, and rtM204I mutant groups.
Result: When the rtM204V and rtM204I mutation groups were compared, all 72 cases of rt
HBV mutation literature information.
PMID: 
2014
Antiviral research
Browser Board
Co-occurred Entities
Filtrator
ViMRT